中国6省18~75岁人群高钙尿症检出情况及影响因素  

The detection of hypercalciuria and influencing factors among people aged 18-75 years old in six provinces of China

作　　者：张贝贝 刘敏[2] 李园 张普洪 白雅敏[2] 吉宁[2] 吴静[2] 徐建伟[2] ZHANG Bei-bei;LIU Min;LI Yuan;ZHANG Pu-hong;BAI Ya-min;JI Ning;WU Jing;XU Jian-wei(Chronic Disease Department of Xiangyang Center for Disease Control and Prevention,Xiangyang 441000,China;National Center for Chronic and Noncommunicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 100050,China;The George Institute for Global Health at Peking University Health Science Center,Beijing 100088,China)

机构地区：[1]襄阳市疾病预防控制中心慢病科,襄阳441000 [2]中国疾病预防控制中心慢性非传染性疾病预防控制中心,北京100050 [3]北京大学医学部乔治健康研究所,北京100088

出　　处：《中华疾病控制杂志》2022年第7期766-770,共5页Chinese Journal of Disease Control & Prevention

基　　金：英国国立健康研究院资助中英减盐项目(16/136/77)。

摘　　要：目的了解中国6省18~75岁人群高钙尿症检出情况及影响因素。为预防高钙尿症及其引发的其他疾病提供依据。方法采用多阶段整群随机抽样方法,抽取中国6省18~75岁2693名调查对象,开展问卷调查、体格检查并收集24 h尿标本,检测24小时尿钙水平(24-hours urinary calcium,24HUC)。结果最终纳入分析2637名研究对象,共检出高钙尿症者258名,高钙尿症检出率为9.78%,其中男性和女性高钙尿症检出率分别是8.47%和11.09%(χ^(2)=5.124,P=0.024)。多因素Logistic回归分析模型分析显示,女性(OR=1.366,95%CI:1.051~1.778,P=0.020)、45~<60岁(OR=2.069,95%CI:1.404~3.049,P<0.001)、超重(OR=1.661,95%CI:1.216~2.268,P=0.001)、肥胖(OR=2.623,95%CI:1.855~3.709,P<0.001)及患糖尿病(OR=1.988,95%CI:1.292~3.060,P=0.002)与高钙尿症的发生相关。结论中国人群高钙尿症检出率较高,建议重点人群应开展24HUC的筛查工作,及早预防高钙尿症及其引发的其他疾病。Objective To investigate the detection of hypercalciuria and influencing factors among people aged 18-75 years old in six Provinces of China,and to provide basis for prevention of hypercalciuria and other diseases.Methods A total of 2693 subjects aged 18-75 years old were selected from 6 provinces in China.Using multi-stage cluster random sampling method.Information were collected through questionnaire survey,physical measurement and 24-hours urine collection(24HUC).The 24-hours urinary calcium level was measured.Results A total of 2637 subjects were included in the final analysis,of which 258 subjects were detected with hypercalciuria,and the detection rate was 9.78%.The male and female hypercalciuria detection rates were 8.47%and 11.09%,respectively(χ^(2)=5.124,P=0.024).Multivariate Logistic regression analysis showed that female(OR=1.366,95%CI:1.051-1.778,P=0.020),people aged 45-<60 years old(OR=2.069,95%CI:1.404-3.049,P<0.001),overweight(OR=1.661,95%CI:1.216-2.268,P=0.001),obesity(OR=2.623,95%CI:1.855-3.709,P<0.001),and people with diabetes mellitus(OR=1.988,95%CI:1.292-3.060,P=0.002)were related with hypercalciuria.Conclusions The detection rate of hypercalciuria in Chinese population is high.It is suggested that 24HUC screening should be carried out in target population to prevent hypercalciuria and other diseases as soon as possible.

关 键 词：高钙尿症 24 h尿钙水平 影响因素 

分 类 号：R181[医药卫生—流行病学]