变态反应性皮肤病445例患者过敏原特异性IgE检测结果分析  

Analysis of allergen specific IgE detection in 445 patients with allergic skin diseases

作　　者：李云珠 路雪艳[2] 郑玲玲 吴凌颖[4] 周向昭 胡立忠[6] 李国英 郑利雄 周乃慧[9] 马学良 李钦峰 周艳[12] 张红 王宝林[14] 李邻峰[1] LI Yun-zhu;LU Xue-yan;ZHENG Ling-ling(Department of dermatology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Peking University Third Hospital,Beijing 100191,China;BeiJing Luhe Hospital,Capital Medical University,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京友谊医院皮肤科,北京100050 [2]北京大学第三医院皮肤科,北京100191 [3]北京潞河医院皮肤科,北京101149 [4]大同市第三人民医院变态反应科,山西大同037000 [5]北方学院附属第一医院皮肤科,河北张家口075000 [6]华北石油管理局总医院皮肤科,河北沧州062552 [7]宁津县人民医院皮肤科,山东德州253000 [8]深圳市人民医院皮肤科,广东深圳518020 [9]苏州大学附属第一医院皮肤科,江苏苏州215006 [10]滕州中心人民医院皮肤科,山东枣庄277500 [11]天津儿童医院皮肤科,天津300134 [12]西安交通大学第一附属医院皮肤科,陕西西安710061 [13]沂南县人民医院皮肤科,山东临沂276300 [14]枣庄市立医院皮肤科,山东枣庄277000

出　　处：《临床和实验医学杂志》2022年第13期1415-1418,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的了解445例变态反应性皮肤病患者过敏原特异性IgE检测结果的差异和特点,进一步探寻特异性IgE检测对疾病预防和临床诊治的意义。方法收集全国14家医院2019年12月至2021年12月间荨麻疹、湿疹及特应性皮炎患者的血清总IgE和特异性IgE检测结果,要求参与者至少存在一项特异性IgE检测结果阳性(≥0.35 IU/mL)。所有患者来源于华东、华南、华北和西北地区,年龄0~86岁。血清检测均使用酶联免疫捕获法进行。根据不同性别、年龄、地区和就诊季节对患者进行分组,结果使用SPSS 22.0软件进行统计分析,了解患者特异性IgE增高与性别、年龄、地区和季节之间的关系。结果在445例存在特异性IgE检测结果阳性的患者中,244例同时血清总IgE增高(≥60 IU/mL),两者不对等。特异性IgE增高检出人数最多的过敏原种类是鸡蛋、粉尘螨、牛奶、屋尘螨和小麦。鸡蛋、牛奶和小麦特异性IgE增高人群主要集中在0~12岁,且特异性IgE均值随着年龄增长逐级递减,差异均有统计学意义(P<0.05)。男性屋尘螨特异性IgE均值为(11.96±26.40)IU/mL,高于女性[(2.78±6.02)IU/mL],华东地区特异性IgE均值为(18.08±34.24)IU/mL,高于西北地区[(1.74±3.98)IU/mL],差异均有统计学意义(P<0.05)。男性患者艾蒿特异性IgE均值为(2.09±2.23)IU/mL,低于女性患者[(39.00±51.25)IU/mL],差异有统计学意义(P<0.05)。结论不同性别、年龄、地区和季节过敏特点存在差异。鸡蛋、粉尘螨、牛奶、屋尘螨和小麦是我国很多地区的主要变应原。血清特异性IgE检测对变态反应性皮肤病的预防、诊断、治疗具有一定价值和意义。Objective To investigate the differences and characteristics of allergen specific IgE detection results in 445 patients with allergic skin diseases,and to further explore the significance of specific IgE detection in disease prevention and clinical diagnosis and treatment.Methods Serum total IgE and specific IgE detection results of patients with urticaria,eczema and atopic dermatitis were collected from 14 hospitals in China from December 2019 to December 2021.They were required to have at least one positive specific IgE test(≥0.35 IU/mL).The patients were from East,South,north and northwest China and ranged in age from 0-86 years old.Serum was detected by Reversed-enzyme allegro-sorbent test(REAST).Patients were divided into groups according to different genders,ages,regions and treatment seasons.SPSS 22.0 software was used for statistical analysis.Results Among the 445 specific IgE positive patients,244 patients had an increase of total serum IgE(≥60IU/ml).The most allergens with the specific IgE detection were egg,dust mite,milk,house dust mite and wheat.The increase of specific IgE in egg,milk and wheat was mainly concentrated in age of 0-12 years old,and the mean value of these specific IgE decreased with the increase of age(P<0.05).The level of specific IgE of house dust mites in males was(11.96±26.40)IU/mL,which was higher than that in females[(2.78±6.02)IU/mL],and the level of specific IgE in East China was(18.08±34.24)IU/mL,which was higher than Northwest region[(1.74±3.98)IU/mL],the differences were statistically significant(P<0.05).The level of specific IgE of artemisia argyi in male patients was(2.09±2.23)IU/mL,which was lower than that in female patients[(39.00±51.25)IU/mL],and the difference was statistically significant(P<0.05).Conclusion There are differences in gender,age,region and season of allergy.Eggs,dust mites,milk,house dust mites and wheat are major allergens in many areas of China.Serum IgE specific IgE detection has certain value and significance for the prevention,diagnosis

关 键 词：变态反应性皮肤病 过敏原特异性IgE检测 吸入性变应原 食入性变应原 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]