复方丹参注射液联合纳洛酮治疗急诊乙醇中毒的效果  

Effect of compound salvia miltiorrhiza injection combined with naloxone in the treatment of emergency alcohol poisoning

作　　者：李云 LI Yun(The First Hospital of Mile,Yunnan Province,Mile 652399,China)

机构地区：[1]弥勒第一医院,云南省弥勒市652399

出　　处：《临床合理用药杂志》2022年第19期22-24,28,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察复方丹参注射液联合纳洛酮治疗急诊乙醇中毒的效果。方法选取2020年1月—2021年1月弥勒第一医院收治的急诊乙醇中毒患者75例,采用随机数字表法分为研究组38例和对照组37例。对照组患者予以纳洛酮治疗,研究组患者在对照组治疗的基础上联合复方丹参注射液治疗。比较2组患者呼吸、意识、肌力恢复时间、治疗前后丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水平、临床疗效及不良反应。结果研究组患者呼吸、意识及肌力恢复时间均短于对照组(P<0.01);治疗后2组患者MDA水平均低于治疗前,GSH-Px、SOD水平均高于治疗前,且研究组降低/升高幅度大于对照组(P<0.01);治疗后,研究组患者的治疗总有效率为94.74%,高于对照组患者的75.68%(χ^(2)=5.442,P=0.020);2组患者不良反应总发生率比较差异无统计学意义(15.79%vs.10.81%,χ^(2)=0.402,P=0.526)。结论急诊乙醇中毒患者应用复方丹参注射液联合纳洛酮治疗可显著缩短患者恢复时间,增强患者治疗效果,且安全性良好。Objective To observe the effect of compound salvia miltiorrhiza injection combined with naloxone in the treatment of emergency alcohol poisoning.Methods 75 patients with emergency alcohol poisoning admitted to the First Hospital of Mile from January 2020 to January 2021 were selected and divided into study group(n=38)and control group(n=37)by random number table method.Patients in the control group were treated with naloxone,and patients in the study group were treated with compound salvia miltiorrhiza injection on the basis of the treatment in the control group.Respiration,consciousness,muscle strength recovery time,malondialdehyde(MDA),glutathione peroxidase(GSH-PX),superoxide dismutase(SOD)levels before and after treatment,clinical efficacy and adverse reactions of 2 groups were compared.Results The recovery time of respiration,consciousness and muscle strength in study group were shorter than that in control group(P<0.01).After treatment,MDA levels in 2 groups were lower than before treatment,GSH-Px and SOD levels were higher than before treatment,and the decrease/increase range in study group was greater than that in control group(P<0.01).After treatment,the total effective rate of study group was 94.74%,which was higher than 75.68%of control group(χ^(2)=5.442,P=0.020).There was no significant difference in the total incidence of adverse reactions between 2 groups(15.79%vs.10.81%,χ^(2)=0.402,P=0.526).Conclusion The combination of compound salvia miltiorrhiza injection and naloxone can significantly shorten the recovery time and enhance the therapeutic effect of patients with emergency alcohol poisoning,with good safety.

关 键 词：乙醇中毒 急诊 复方丹参注射液 纳洛酮 意识恢复 不良反应 

分 类 号：R595.6[医药卫生—内科学]