小剂量阿奇霉素联合孟鲁司特钠治疗小儿反复下呼吸道感染的效果  

Effect of low-dose azithromycin combined with montelukast sodium on children with recurrent lower respiratory tract infection

作　　者：张生辉 林益斌 ZHANG Shenghui;LIN Yibin(Department of Pediatrics,the Second Hospital of Zhangzhou City in Fujian Province,Fujian,Zhangzhou 363199,China)

机构地区：[1]福建省漳州市第二医院儿科,福建漳州363199

出　　处：《中国医药科学》2022年第14期65-68,共4页China Medicine And Pharmacy

摘　　要：目的分析小剂量阿奇霉素(AZI)同孟鲁司特钠对于小儿反复下呼吸道感染(RLRTI)的治疗效果。方法选取2020年1月至2021年1月福建省漳州市第二医院儿科治疗的80例RLRTI患儿。按照随机数表法分组,研究组40例采取小剂量AZI同孟鲁司特钠治疗,对照组40例采取小剂量AZI单纯治疗,比较总有效率、不良反应发生率、不同时间段复发率、实验室指标。结果研究组患儿的总有效率高于对照组,差异有统计学意义(P<0.05)。研究组患儿的不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。随访6个月,研究组患儿在不同时间段的复发率低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿中性粒细胞(N)、白细胞计数(WBC)、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)和总免疫球蛋白E(IgE)指标比较,差异无统计学意义(P>0.05)。随访6个月,两组患儿N、WBC、PCT、hs-CRP、总IgE指标较治疗前均有所改善,其中研究组患儿的各项指标均低于对照组,差异有统计学意义(P<0.05)。结论为RLRTI患儿采取小剂量AZI同孟鲁司特钠治疗可以提升疗效,减少药物不良反应,抑制疾病复发,且能改善实验室指标,具有较高的用药价值。Objective To analyze the therapeutic efficacy of low-dose azithromycin(AZI)combined with montelukast sodium on children with recurrent lower respiratory tract infection(RLRTI).Methods A total of 80 children with RLRTI admitted to and treated in the Department of Pediatrics of the Second Hospital of Zhangzhou City in Fujian Province from January 2020 to January 2021 were selected.They were divided into the study group(n=40)and the control group(n=40)according to the random number table method.The study group was treated with low-dose AZI combined with montelukast sodium,while the control group was treated with low-dose AZI alone.The overall response rate,adverse reactions(ADRs)rate,recurrence rates in different periods and laboratory indices were compared between the two groups.Results The overall response rate of the study group was higher than that of the control group,with statistically significant differences(P<0.05).The total ADRs rate of children in the study group was lower than that in the control group,with statistically significant differences(P<0.05).After 6 months of follow-up,the recurrence rates of children in different periods in the study group were lower than those in the control group,with statistically significant differences(P<0.05).Before treatment,there were no statistically significant contrast differences in indices of neutrophils(N),white blood cell count(WBC),procalcitonin(PCT),high sensitivity C-reactive protein(hs-CRP)and immunoglobulin E(IgE)between the two groups of children(P>0.05).After 6 months of follow-up,the indices of N,WBC,PCT,hs-CRP and total IgE between the two groups of children were all improved to a certain extent compared with those before treatment,among them,all indices of children in the study group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion The treatment of low-dose AZI combined with montelukast sodium for children with RLRTI can improve the therapeutic efficacy,reduce ADRs of drugs,inhibit disease recurre

关 键 词：小剂量阿奇霉素 孟鲁司特钠 小儿反复下呼吸道感染 复发率 不良反应 

分 类 号：R725.6[医药卫生—儿科]