健脾Ⅰ号治疗脾虚型功能性消化不良的临床效果  

Clinical effect of Jianpi No.1 Decoction in the treatment offunctional dyspepsia due to spleen deficiency

作　　者：陈亮 余求祥[2] 刘泽洲 黄凤[4] 王和天[4] CHEN Liang;YU Qiuxiang;LIU Zezhou;HUANG Feng;WANG Hetian(Department of Gastroenterology,Beijing First Hospital of Integrated Chinese and Western Medicine,Beijing 100026,China;Department of Anorectal Surgery,China-Japan Friendship Hospital,Beijing 100029,China;Department of Internal Medicine,Kangzhuang Community Health Service Station of Langfang City in Hebei Province,Hebei,Langfang 065000,China;Department of Internal Medicine,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China)

机构地区：[1]北京市第一中西医结合医院消化内科,北京100026 [2]中日友好医院肛肠科,北京100029 [3]河北省廊坊康庄社区卫生服务站内科,河北廊坊065000 [4]首都医科大学附属北京中医医院内科,北京100010

出　　处：《中国医药科学》2022年第13期10-13,61,共5页China Medicine And Pharmacy

基　　金：国家自然科学基金(81503580);北京市朝阳区科技计划项目(CYSF1625)。

摘　　要：目的 评价健脾Ⅰ号治疗脾虚型功能性消化不良的临床效果。方法 按照罗马Ⅳ功能性消化不良及中医脾虚证诊断标准,收集2020年7月至2021年6月就诊于北京市第一中西医结合医院CBD院区及中医院区消化科门诊并明确诊断为功能性消化不良的患者131例,采用随机数字表法分为治疗组(n=67)和对照组(n=64),治疗组给予健脾Ⅰ号散剂口服治疗,对照组给予四君子颗粒口服治疗,疗程均为4周。按照尼莫地平法对患者治疗前后的症状和证候积分进行比较分析。结果 治疗组患者治疗总有效率为95.52%,高于对照组的85.94%,差异有统计学意义(P <0.05)。治疗后,治疗组的证候积分低于对照组,差异有统计学意义(P <0.05)。治疗组餐后饱胀不适、上腹烧灼感、体倦乏力、大便稀溏症状的总改善率优于对照组,差异有统计学意义(P <0.05)。两组不良反应发生率均较低且差异无统计学意义(P> 0.05)。结论 健脾Ⅰ号散剂治疗脾虚型功能性消化不良,临床疗效确切,不仅制剂简便且具有更高的药材利用率,适宜临床推广应用。Objective To evaluate the clinical effect of Jianpi No.1 Decoction in the treatment of functional dyspepsia due to spleen deficiency. Methods According to the diagnostic criteria of Rome Ⅳ functional dyspepsia and spleen deficiency syndrome in traditional Chinese medicine(TCM), a total of 131 patients clearly diagnosed with functional dyspepsiawho were admitted to the outpatient in the Department of Gastroenterology of the CBD branch and TCM branch in the Beijing First Hospital of Integrated Chinese and Western Medicine from July 2020 to June 2021 were collected. And they were divided into treatment group(n=67) and control group(n=64) by random number table method, The treatment group was given Jianpi No.1 Decoction orally, while the control group was given Sijunzi Granule orally, both with a treatment course of 4 weeks. According to nimodipine method, the symptoms and syndrome scores of patients before and after treatment were compared and analyzed. Results The total effective rate in the treatment group was 95.52%, which was higher than 85.94%in the control group, and the difference was statistically significant(P < 0.05). After treatment, the syndrome scores of the treatment group were lower than those of the control group, and the differences were statistically significant(P < 0.05). The overall improvement rate of the treatment group was superior to that of the control group in relieving the symptoms such as postprandial fullness and discomfort, upper abdominal burning, fatigue and weakness, and loose stool, and the difference was statistically significant(P < 0.05). The incidences of adverse reactions were lower in both groups and the difference was not statistically significant(P > 0.05). Conclusion Jianpi No.1 Decoction has a definite clinical efficacy in the treatment of functional dyspepsia due to spleen deficiency. It is not only simple in preparation, but also has a higher utilization rate of medicinal materials.Therefore, it is suitable for clinical promotion and application.

关 键 词：健脾Ⅰ号 功能性消化不良 脾虚证 中药煮散 

分 类 号：R256.3[医药卫生—中医内科学]