酚妥拉明联合多巴胺治疗小儿肺炎合并心力衰竭的临床疗效及其对患儿心肌酶谱的影响  

Clinical effect of phentolamine combined with dopamine in the treatment of infantile pneumonia complicated with heart failure and the impact on myocardial enzyme spectrum of childeren

作　　者：聂丹 NIE Dan(Department of Paediatrics,Lianyuan People′s Hospital,Lianyuan 417100,China)

机构地区：[1]湖南省涟源市人民医院儿科,417100

出　　处：《临床合理用药杂志》2022年第21期23-25,29,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察酚妥拉明联合多巴胺治疗小儿肺炎合并心力衰竭的临床疗效及其对患儿心肌酶谱的影响。方法回顾性选取2018年2月—2021年1月涟源市人民医院收治的肺炎合并心力衰竭患儿50例,按照治疗方法分为对照组和试验组,各25例。对照组采用常规药物治疗,试验组在对照组基础上予以酚妥拉明联合多巴胺治疗,2组均连续治疗3 d。比较2组临床疗效、症状改善时间,治疗前后心率、血氧饱和度、呼吸频率、心肌酶谱指标[乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)],不良反应。结果试验组总有效率为96.00%,高于对照组的76.00%(χ^(2)=4.153,P=0.042)。试验组呼吸恢复正常时间、心率恢复正常时间、心力衰竭症状消失时间、住院时间短于对照组(P<0.01)。治疗后,2组心率、呼吸频率低于治疗前,血氧饱和度高于治疗前,且试验组心率、呼吸频率低于对照组,血氧饱和度高于对照组(P<0.01)。治疗后,2组LDH、CK、CK-MB水平低于治疗前,且试验组低于对照组(P<0.01)。2组治疗期间不良反应总发生率比较,差异无统计学意义(P>0.05)。结论酚妥拉明联合多巴胺治疗小儿肺炎合并心力衰竭的临床效果较明显,可快速改善患儿的临床症状,缩短住院时间,降低心肌酶谱指标,且安全性较高。Objective To observe clinical effect of phentolamine combined with dopamine in the treatment of infantile pneumonia complicated with heart failure and the impact on myocardial enzyme spectrum of childeren.Methods A total of 50 cases of infantile pneumonia complicated with heart failure were selected retrospectively from February 2018 to January 2021 in Lianyuan People′s Hospital,and they were divided into control group and experimental group by treatment therapy,25 cases in each group.Patients in control group were given routine medicine treatment,patients in experimental group were given phentolamine combined with dopamine based on control group,both groups were treated with 3 days.Clinical effect,improvement time of symptoms,heart rate,oxygen saturation,respiratory rate,myocardial enzyme spectrum indexes(LDH,CK,CK-MB)before and after treatment,incidence of adverse reactions were compared between the two groups.Results Total effective rate in experimental group was 96.00%,higher than 76.00%in control group(χ^(2)=4.153,P=0.042).Recover normal time of breathing,recover normal time of heart rate,disappearing time of heart failure symptoms,hospital stay in experimental group were shorter than those in control group(P<0.01).After treatment,heart rate,respiratory rate in the two groups were lower than those before treatment,oxygen saturation was higher than that before treatment,and heart rate,respiratory rate in experimental group were lower than those in control group,oxygen saturation was higher than that in control group(P<0.01).After treatment,levels of LDH,CK,CK-MB in the two groups were lower than those before treatment,and the experimental group were lower than those in control group(P<0.01).There was no significant difference of incidence of adverse reactions between the two groups(P>0.05).Conclusion Phentolamine combined with dopamine have an obviously clinical effect in the treatment of infantile pneumonia complicated with heart failure,which can effectively improve clinical symptoms of children,shorten

关 键 词：肺炎 心力衰竭 儿童 酚妥拉明 多巴胺 治疗结果 

分 类 号：R725[医药卫生—儿科]