中西医结合治疗对特发性水肿患者抗氧化能力及血液流变学指标的影响  

Effect of Integrated Traditional Chinese and Western Medicine on Antioxidant Capacity and Hemorheology in Patients with Idiopathic Edema

作　　者：王欣然 WANG Xinran(Jiangning District Hospital of Traditional Chinese Medicine in Nanjing City,Nanjing 211100,China)

机构地区：[1]南京市江宁中医院,江苏南京211100

出　　处：《中国医学创新》2022年第21期74-77,共4页Medical Innovation of China

摘　　要：目的:探讨中西医结合治疗对特发性水肿患者抗氧化能力和血液流变学指标的影响,以期为临床治疗提供参考。方法:选取2019年4月-2020年12月在南京市江宁中医院就诊的94例特发性水肿患者为研究对象,根据随机抽签的方式分为对照组和观察组,每组47例。对照组给予口服氢氯噻嗪片,观察组在此基础上加用自拟祛湿逐瘀利水组方汤剂。比较两组临床疗效、抗氧化能力[血清超氧化物歧化酶(SOD)、丙二醛(MDA)和一氧化氮(NO)]、血液流变学指标(全血高切黏度、全血中切黏度、全血低切黏度以及血浆黏度)及不良反应发生情况。结果:对照组临床治疗的总有效率为82.98%,观察组临床治疗的总有效率为95.74%,两组间差异有统计学意义(P<0.05)。对照组和观察组治疗前SOD、MDA和NO水平比较,差异均无统计学意义(P>0.05),治疗后两组SOD均升高,观察组高于对照组(P<0.05);治疗后两组MDA和NO均降低,观察组均低于对照组(P<0.05)。对照组和观察组治疗前全血高切黏度、全血中切黏度、全血低切黏度以及血浆黏度比较,差异均无统计学意义(P>0.05),对照组治疗前后上述指标比较,差异均无统计学意义(P>0.05),观察组治疗后上述血液流变学指标均低于治疗前及对照组治疗后(P<0.05)。对照组用药期间不良反应发生率为21.28%,观察组不良反应发生率为4.26%,两组间差异有统计学意义(P<0.05)。结论:中西医结合治疗特发性水肿患者临床效果显著,且不良反应少,可能与有效改善患者抗氧化能力和血液流变学指标密切相关。Objective:To explore the effect of integrated traditional Chinese and Western medicine on antioxidant capacity and hemorheological indexes in patients with idiopathic edema,in order to provide reference for clinical treatment.Method:A total of 94 patients with idiopathic edema treated in Jiangning District Hospital of Traditional Chinese Medicine in Nanjing City from April 2019 to December 2020 were randomly divided into control group and observation group,with 47 cases in each group.The control group was given oral Hydrochlorothiazide Tablets,the observation group was added with self-made Qushi Zhuyu Lishui Decoction on this basis.The clinical efficacy,antioxidant capacity[serum superoxide dismutase(SOD),malondialdehyde(MDA)and nitric oxide(NO)],hemorheological indexes(whole blood high shear viscosity,whole blood medium shear viscosity,whole blood low shear viscosity and plasma viscosity)and the incidence of adverse reactions were compared between the two groups.Result:The total effective rate of clinical treatment in the control group was 82.98%,and that in the observation group was 95.74%,there was significant difference between the two groups(P<0.05).There was no significant difference in the levels of SOD,MDA and NO between the control group and the observation group before treatment(P>0.05).After treatment,SOD increased in both groups,that was higher in the observation group than that in the control group(P<0.05);after treatment,MDA and NO decreased in both groups,and the levels of MDA and NO in the observation group were lower than those in the control group(P<0.05).There were no significant differences in the whole blood high shear viscosity,whole blood medium shear viscosity,whole blood low shear viscosity and plasma viscosity between the control group and the observation group before treatment(P>0.05).There were no significant differences in the above indexes before and after treatment in the control group(P>0.05).The above hemorheological indexes in the observation group after treatment were lower than

关 键 词：特发性水肿 抗氧化 血液流变学指标 中西医治疗 

分 类 号：R442.5[医药卫生—诊断学]