Diabetic kidney disease in pediatric patients: A current review  

作　　者：Carmen Muntean Iuliana Magdalena Starcea Claudia Banescu 

机构地区：[1]Department of Pediatrics I,“George Emil Palade”University of Medicine,Pharmacy,Sciences and Technology of Târgu Mures,Târgu Mures 540142,Romania [2]Department of IVth Pediatrics,University of Medicine and Pharmacy“Grigore T.Popa”,Iasi 700115,Romania [3]Center for Advanced Medical and Pharmaceutical Research,University of Medicine,Pharmacy,Sciences and Technology of Târgu Mureș,Mureș,Târgu Mures 540142,Romania

出　　处：《World Journal of Diabetes》2022年第8期587-599,共13页世界糖尿病杂志（英文版）（电子版）

摘　　要：In the last decades,a significant increase in the incidence of diabetic kidney disease(DKD)was observed concomitant with rising diabetes mellitus(DM)incidence.Kidney disease associated with DM in children and adolescents is represented by persistent albuminuria,arterial hypertension,progressive decline in estimated glomerular filtration rate to end-stage renal disease and increased cardiovascular and all-cause morbidity and mortality of these conditions.In medical practice,the common and still the“gold standard”marker for prediction and detection of diabetic kidney involvement in pediatric diabetes is represented by microalbuminuria screening even if it has low specificity to detect early stages of DKD.There are some known limitations in albuminuria value as a predictor biomarker for DKD,as not all diabetic children with microalbuminuria or macroalbuminuria will develop end-stage renal disease.As tubular damage occurs before the glomerular injury,tubular biomarkers are superior to the glomerular ones.Therefore,they may serve for early detection of DKD in both type 1 DM and type 2 DM.Conventional and new biomarkers to identify diabetic children and adolescents at risk of renal complications at an early stage as well as renoprotective strategies are necessary to delay the progression of kidney disease to end-stage kidney disease.New biomarkers and therapeutic strategies are discussed as timely diagnosis and therapy are critical in the pediatric diabetic population.

关 键 词：DIABETES Kidney disease Biomarkers MICROALBUMINURIA THERAPY CHILDREN 

分 类 号：R725.8[医药卫生—儿科] R726.9[医药卫生—临床医学]