Compound-honeysuckle-induced drug eruption with special manifestations:A case report  

作　　者：Li-Feng Zhou Rong Lu 

机构地区：[1]Department of Dermatology,The 942nd Hospital of the People's Liberation Army Joint Logistic Support Force,Yinchuan 750004,Ningxia Hui Autonomous Region,China [2]Department of Pathology,The 942nd Hospital of the People's Liberation Army Joint Logistic Support Force,Yinchuan 750004,Ningxia Hui Autonomous Region,China

出　　处：《World Journal of Clinical Cases》2022年第22期8018-8024,共7页世界临床病例杂志

摘　　要：BACKGROUND The clinical manifestations of drug eruption are complex and diverse,which can lead to missed diagnosis or misdiagnosis.The clinical manifestations of drug eruption caused by compound honeysuckle have not been reported.CASE SUMMARY A 20-year-old man was admitted to our department of dermatology due to erythema and papules on the chest and abdomen with pruritus for 3 d.The next day after taking compound honeysuckle granules,the patient suddenly developed a rash and intense itching on his chest and abdomen.Physical examination revealed diffuse red needle-cap size macules and papules with welldefined borders on the chest and abdomen,and discoloration after finger pressure.No abnormality was observed in other areas of the skin.Back skin scratch was positive.White blood cells,eosinophil count and eosinophil ratio were higher than normal.Histopathological examination of the skin lesions on the left abdomen revealed intercellular edema,blurred focal basal cell layers,and focal lymphocyte infiltration in the superficial dermis and perivascular areas.Immunohistochemistry showed CD3+,CD4+and CD8+T lymphocytes.The diagnosis was drug eruption with special manifestations induced by compound honeysuckle.The skin lesions completely subsided without pruritus after 2 wk of antihistamine and hormone therapy.Follow-up for>1 mo showed no recurrence.CONCLUSION Chinese patent medicine compound honeysuckle granules can induce allergic reaction and rare skin damage.

关 键 词：Drug eruption Drug dermatitis Blaschko line Compound honeysuckle Allergic reaction Case report 

分 类 号：R285.6[医药卫生—中药学]