中药治疗小儿轮状病毒性腹泻的Meta分析  

Meta-analysis of traditional Chinese medicine in the treatment of infantile rotavirus diarrhea

作　　者：何玉箫 罗莹 白娜 HE Yuxiao;LUO Ying;BAI Na

机构地区：[1]成都中医药大学附属医院,四川成都610075

出　　处：《中医临床研究》2022年第12期80-85,共6页Clinical Journal Of Chinese Medicine

摘　　要：目的:系统评价中药治疗小儿轮状病毒性腹泻的有效性及安全性。方法:计算机检索数据库中与小儿轮状病毒性腹泻有关的随机对照试验,由两名研究者独立对符合纳入标准的文献进行严格的质量评价和资料提取,应用Revman5.4软件进行Meta分析。结果:与西医治疗方案相比,试验组在治疗小儿病毒性腹泻均能显著提高临床疗效,中药附加常规补液总有效率[OR=4.05,95%CI(2.90,5.65),P<0.00001],有效缩短止泻时间[MD=-0.51,95%CI(-0.69,-0.33),P<0.00001],有效缩短退热时间[MD=-0.29,95%CI(-0.44,-0.15),P<0.0001],有效缩短止吐时间[MD=-0.24,95%CI(-0.34,-0.13),P<0.0001],提高病毒转阴率[OR=2.21,95%CI(1.17,3.86),P=0.01];纯中药组的总有效率[OR=3.25,95%CI(2.05,5.14),P<0.00001],有效缩短退热时间[MD=-0.42,95%CI(-0.44,-0.29),P=0.005],有效缩短止泻时间[MD=-0.59,95%CI(-0.71,-0.48),P<0.00001],有效缩短止吐时间[MD=-0.29,95%CI(-0.50,-0.08),P=0.007],各项差异均具有统计学意义,且两组均未出现不良反应的报道。结论:较西医治疗,中药治疗小儿轮状病毒性腹泻安全有效,缩短病程,提高轮状病毒转阴率。为提高研究的质量,仍需要更加严谨地设计多中心、大数据的随机对照试验支持。Objective:To systematically evaluate the effectiveness and safety of traditional Chinese medicine in the treatment of rotavirus diarrhea in children.Methods:Randomized controlled trials(Rcts)related to rotavirus diarrhea in children were retrieved from the database by computer.Two researchers independently carried out strict quality evaluation and data extraction for the literatures meeting the inclusion criteria,and meta-analysis was performed using Revman5.4 software.Results:Compared with western medicine treatment plan,the experimental group can significantly improve the clinical efficacy in the treatment of rotavirus diarrhea in children,the total effective rate of traditional Chinese medicine plus conventional fluid replenishing[OR=4.05,95%CI(2.90,5.65),P<0.00001],effectively shortened the antidiarrheal time[MD=-0.51,95%CI(-0.69,-0.33),P<0.00001],effectively shortened the time of antipyretic[MD=-0.29,95%CI(-0.44,-0.15),P<0.0001],effectively shortened the time of antiemetic[MD=-0.24,95%CI(-0.34,-0.13),P<0.0001],Increased virus negative rate[OR=2.21,95%CI(1.17,3.86),P=0.01];the total effective rate of the pure Chinese medicine group[OR=3.25,95%CI(2.05,5.14),P<0.00001],effectively shortened the antipyretic time[MD=-0.42,95%CI(-0.44,-0.29),P=0.005],effectively shortened the antidiarrheal time[MD=-0.59,95%CI(-0.71,-0.48),P<0.00001],effectively shortened the antiemetic time[MD=-0.29,95%CI(-0.50,-0.08),P=0.007],the differences were statistically significant,and there were no reports of adverse reactions in both groups.Conclusion:Compared with western medicine treatment,traditional Chinese medicine is more safe and effective in treating rotavirus diarrhea in children,it can shorten the course of disease and improve the rotavirus negative conversion rate.In order to improve the quality of studies,more rigorous design and support of multi-center,large-data randomized controlled trials are still needed.

关 键 词：中药 轮状病毒 腹泻 META分析 

分 类 号：R442.2[医药卫生—诊断学]