重视HBsAg定量检测在慢性乙型肝炎全程管理中的价值  

Importance of quantitative HBsAg detection in whole course management of patients with chronic hepatitis B

作　　者：封波[1] 郑佳睿 Bo Feng;Jia-Rui Zheng(Department of Hepatology,Peking University People’s Hospital,Peking University Hepatology Institute,Beijing 100044,China)

机构地区：[1]北京大学人民医院,北京大学肝病研究所,北京市100044

出　　处：《世界华人消化杂志》2022年第15期655-660,共6页World Chinese Journal of Digestology

基　　金：国家科技重大专项-艾滋病和病毒性肝炎等重大传染病防治资助项目,No.2017ZX10302201-004-001,No.2017ZX10203202-003-003.

摘　　要：乙型肝炎病毒表面抗原(hepatitis B virus surface antigen,HBsAg)是最早发现的关于乙型肝炎病毒(hepatitis B,HBV)的血清标志物,在慢性乙型肝炎(chronic hepatitis B,CHB)发病机制、诊断、预防等方面发挥了重要作用.随着CHB进入抗病毒治疗时代以及功能性治愈概念的提出,HBsAg作为HBV感染的老指标,在CHB患者管理中被发现有越来越多的新价值.特殊CHB患者以HBsAg阳性作为抗病毒治疗的适应症,HBsAg水平高低有助于治疗方案的选择,HBsAg的动力学有助于治疗期间方案的调整,HBsAg水平及其变化趋势可以预测疗效及疾病的结局、并指导停药.针对HBsAg的灵敏度、作为功能性治愈标志物、对远期结局的影响及在彻底治愈中的价值等方面,需要进一步研究.HBsAg is the earliest known serum marker for hepatitis B virus(HBV).It plays an important role in the pathogenesis,diagnosis,and prevention of chronic hepatitis B(CHB).In the era of antiviral therapy,the concept of functional cure is put forward.HBsAg,as an old marker of HBV infection,has been found to have more and more new applications in the management of CHB patients.Positive HBsAg is taken as the indication of antiviral treatment in special CHB patients.The level of HBsAg is conducive to the selection of treatment regimens,and the dynamics of HBsAg is conducive to the adjustment of treatment scheme.HBsAg level and its kinetics can predict the therapeutic effect and disease outcome,and guide drug withdrawal.Further research is needed on the sensitivity of HBsAg,its impact on long-term outcomes,and its value in functional cure and complete cure.

关 键 词：慢性乙型肝炎 乙型肝炎病毒表面抗原 抗病毒治疗 

分 类 号：R512.62[医药卫生—内科学]