扶阳解毒颗粒联合高效抗逆转录病毒治疗对人类免疫缺陷病毒/获得性免疫缺陷综合征患者临床疗效评价的回顾性分析  

A retrospective analysis of clinical efficacy of the Fuyang Jiedu granules plus highly active antiretroviral therapy on human immunodeficiency virus/acquired immunodeficiency syndrome

作　　者：刘晶晶[1] 严一凯 彭鑫 杨欣怡 吴亚梅[1] 张毅[1] 阎玉萍[3] 周天玉[1] LIU Jingjing

机构地区：[1]四川省中医药科学院,四川成都610041 [2]越西县第一人民医院,四川越西616650 [3]凉山州中西医结合医院,四川西昌615000

出　　处：《中医临床研究》2022年第19期21-24,共4页Clinical Journal Of Chinese Medicine

基　　金：四川省科技厅重点研发项目-针对低依从性HIV感染者中医协同治疗方案的临床研究(2020YFS0369);四川省科技厅重点研发项目-基于邪气正安思想探索愈疡胶囊联合HAART促进HIV感染者免疫重建、延缓发病的前瞻性临床研究(2019YFS0023)

摘　　要：目的:分析扶阳解毒颗粒联合高效抗逆转录病毒治疗人类免疫缺陷病毒/获得性免疫缺陷综合征的临床疗效及安全性。方法:筛选出符合纳入标准的人类免疫缺陷病毒/获得性免疫缺陷综合征患者,采用回顾性自身前后对照的试验设计,比较用药前后CD4^(+)T淋巴细胞计数、病毒载量的变化,同时统计出用药期间出现的不良反应。结果:71例人类免疫缺陷病毒/获得性免疫缺陷综合征患者在使用扶阳解毒颗粒联合高效抗逆转录病毒治疗1年后,CD4^(+)T淋巴细胞计数上升,差异有统计学意义(P<0.05)。对基线CD4^(+)T淋巴细胞分层后再分析,显示扶阳解毒颗粒联合高效抗逆转录病毒治疗可以显著提高CD4^(+)T淋巴细胞计数低于350个/μL的人类免疫缺陷病毒/获得性免疫缺陷综合征患者的CD4细胞计数,差异具有统计学意义(P<0.05);从病毒载量的变化来看,本方案治疗前后人类免疫缺陷病毒/获得性免疫缺陷综合征患者病毒载量的变化有统计学意义(P<0.05);用药期间未见明显不良反应。结论:扶阳解毒颗粒联合高效抗逆转录病毒治疗,具有提高人类免疫缺陷病毒/获得性免疫缺陷综合征患者CD4^(+)T淋巴细胞、提高抗病毒治疗有效率的作用,尤其适用于CD4^(+)T淋巴细胞计数低于350个/μL的患者,同时具有良好的安全性。Objective:To analyze the clinical efficacy and safety of the Fuyang Jiedu granules(扶阳解毒颗粒)plus highly active antiretroviral therapy on patients with human immunodeficiency virus/acquired immunodeficiency syndrome.Methods:Patients with HIV/AIDS who met the inclusion criteria were selected.The changes of CD4^(+)T lymphocyte count and virus load before and after treatment were compared through the retrospective self-control experimental design,and the adverse reactions during the treatment period were counted.Results:After one year of treatment with the Fuyang Jiedu granules plus HAART,the CD4^(+)T lymphocyte count of 71 patients with HIV/AIDS was increased,and the difference was statistically significant(P<0.05).The analysis after stratification of baseline CD4^(+)T lymphocytes showed that the Fuyang Jiedu granules plus HAART could significantly increase the CD4^(+)T lymphocyte count in patient with T lymphocyte count below 350/μL.The difference of CD4 cell count in HIV/AIDS patients was statistically significant(P<0.05).The change of viral load in HIV/AIDS patients before and after treatment was statistically significant(P<0.05).No obvious adverse reaction was observed during the treatment.Conclusion:The Fuyang Jiedu granules plus HAART can improve CD4^(+)T lymphocytes of HIV/AIDS patients and the effective rate of antiviral treatment,especially for CD4^(+)T lymphocyte count less than 350/μL patients,with a good safety.

关 键 词：人类免疫缺陷综合征 扶阳解毒颗粒 CD4^(+)T淋巴细胞 

分 类 号：R512.91[医药卫生—内科学]