溴隐亭及多巴丝肼对颅脑损伤长期昏迷患者的促醒治疗临床观察  

Clinical observation of patients with long-term coma due to craniocerebral injury treated with bromocryptotine and doserazid

作　　者：黄云峰 向鹏 梅敏 樊天禹 HUANG Yun-feng;XIANG Peng;MEI Min;FAN Tian-yu(Changsha Central Hospital,University of South China,Changsha 410004)

机构地区：[1]南华大学附属长沙中心医院,长沙410004

出　　处：《中南药学》2022年第7期1684-1687,共4页Central South Pharmacy

基　　金：湖南省自然科学基金面上项目(No.2020JJ4637)。

摘　　要：目的观察在常规治疗基础上联合溴隐亭和多巴丝肼对颅脑损伤长期昏迷微意识状态患者的促醒治疗效果。方法以2010年1月-2021年5月在我院进行治疗的48例颅脑损伤术后1月仍昏迷、评估为微意识状态患者进行随机分组研究,分为观察组与对照组,对照组患者接受营养支持、扩血管、高压氧以及功能锻炼等常规治疗,观察组患者接受与对照组相同的常规治疗,并加用溴隐亭和多巴丝肼联合治疗。结果治疗3个月后,观察组与对照组格拉斯哥(GCS)评分分别为(10.86±2.43)、(8.49±3.06),差异具有统计学意义(P=0.021),两组分别与治疗前比较GCS评分差异均具有统计学意义(P<0.05)。治疗6个月后,观察组与对照组患者GCS评分分别为(11.97±3.69)、(9.87±3.56),差异具有统计学意义(P=0.005),并且观察组与治疗前比较GCS评分差异具有统计学意义(P<0.01)。治疗6个月后观察组患者意识恢复7例(25.93%),而对照组患者仅有2例(9.52%),差异具有统计学意义(P=0.004)。治疗后对照组重残率为33.33%,明显比观察组(14.81%)高,差异具有统计学意义(P=0.022)。治疗后观察组与对照组中持续性植物状态的患者分别为5例(18.52%)、9例(42.86%),差异具有统计学意义(P=0.030)。两组均死亡1例。结论在常规治疗的基础上联用溴隐亭和多巴丝肼对颅脑损伤后长期昏迷微意识状态患者有良好促醒作用,可改善患者预后。Objective To observe the effect of bromocryptotine and doserazid combination on patients with long-term coma and micro-consciousness after brain injury.Methods Totally 48 patients with long-term coma after craniocerebral injury treated in our hospital from January 2010 to May 2021 were selected as the subjects.They were randomly divided into an observation group and a control group.Patients in the control group received nutrition support,blood vessel expansion,hyperbaric oxygen therapy and functional exercise routine treatment,while patients in the observation group received bromocriptine and benserazide combination therapy besides the same routine therapy.Results After 3 months of treatment,the GCS scores of the observation group and the control group were(10.86±2.43)and(8.49±3.06)with significant difference(P=0.021).The differences as compared with those before the treatment in both groups were significant(P<0.05).After 6 months of treatment,the GCS scores of the observation group and the control group were(12.97±3.69)and(9.87±3.56)with significant difference(P=0.005).The difference in the observation group before and after the treatment was significant(P<0.01).After 6 months of treatment 7 patients in the observation group recovered consciousness(25.93%),while in the control group had only 2(9.52%)(P=0.004).After the treatment,the disability rate in routine treatment group was 33.33%,much higher than that of the observation group(14.81%)(P=0.022).After the treatment,5 patients(18.52%)and 9 patients(42.86%)were in persistent vegetative state with significant difference(P=0.030).One patient died in both groups.Conclusion Besides routine treatment,the combination of bromocystine and doserazid has a good effect on awakening and improving the prognosis of patients with long-term coma and micro-consciousness after brain injury.

关 键 词：溴隐亭 多巴丝肼 长期昏迷 颅脑损伤 促醒 

分 类 号：R95[医药卫生—药学]