RhCcEe配合性血液输注对温抗体型AIHA患者输血安全性的影响  

Effect of RhCcEe Compatible Blood Transfusion on the Safety of Blood Transfusion in Patients with Warm Antibody Autoimmune Hemolytic Anemia

作　　者：邱启东 阙庆和 钟昌瑞 陈维媚 QIU Qidong;QUE Qinghe;ZHONG Changrui;CHEN Weimei(Longyan First Affiliated Hospital of Fujian Medical University,Longyan 364000,China;不详)

机构地区：[1]福建医科大学附属龙岩第一医院,福建龙岩364000

出　　处：《中国医学创新》2022年第22期144-148,共5页Medical Innovation of China

摘　　要：目的:探讨RhCcEe配合性血液输注对温抗体型自身免疫性溶血性贫血(autoimmune hemolytic anemia,AIHA)患者输血安全性的影响。方法:选取2017年1月-2021年12月福建医科大学附属龙岩第一医院收治的98例温抗体型AIHA患者,随机分为对照组和观察组,各49例,对照组给予ABO、RhD相合性输血,观察组给予ABO、RhC、c、D、E、e抗原相合性或相容性输血,比较两组临床疗效、血液学指标、输血不良反应情况。结果:两组性别、年龄、贫血程度等一般资料比较差异无统计学意义(P>0.05)。观察组输注有效44例(89.79%),部分有效3例(6.12%),无效2例(4.08%),总有效率95.92%;对照组输注有效31例(63.26%),部分有效14例(28.57%),无效4例(8.16%),总有效率91.84%,两组输注总有效率比较,差异无统计学意义(P>0.05);两组输血前Hb、Hct、TBIL水平比较,差异均无统计学意义(P>0.05);输血后观察组Hb、Hct水平高于对照组,TBIL水平低于对照组(P<0.05);观察组过敏2例(4.08%),无皮疹,无非溶血性发热,不良反应发生率为4.08%;对照组过敏1例(2.04%),无皮疹,非溶血性发热2例(4.08%),不良反应发生率为6.12%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:RhCcEe配合性血液输注能改善温抗体型AIHA患者Hb、Hct、TBIL水平,且不增加输血不良反应,安全性好。Objective:To investigate the effect of RhCcEe compatible blood transfusion on the safety of blood transfusion in patients with warm antibody autoimmune hemolytic anemia (AIHA).Method:A total of 98 patients with warm antibody AIHA treated in Longyan First Affiliated Hospital of Fujian Medical University from January 2017 to December 2021 were randomly divided into control group (n=49) and observation group (n=49).The control group was given ABO and RhD compatible blood transfusion,and the observation group was given ABO,RhC,c,D,E,e antigen compatible or compatible blood transfusion.The clinical efficacy,hematological indexes and adverse reactions of blood transfusion were compared between the two groups.Result:There was no significant difference in sex,age,degree of anemia and other general data between the two groups (P>0.05).In the observation group,44 cases (89.79%) were effective,3 cases (6.12%) were partially effective,2 cases (4.08%) were ineffective,and the total effective rate was 95.92%.In the control group,31 cases (63.26%) were effective,14 cases (28.57%) were partinally effective,4 cases (8.16%) were ineffective,and the total effective rate was 91.84%.There was no significant difference between the two groups (P>0.05).There were no significant differences in the levels of Hb,Hct and TBIL between the two groups before treatment (P>0.05).After treatment,the levels of Hb and Hct in the observation group were higher than those in the control group,while the level of TBIL in the observation group was lower than that in the control group (P0.05).Conclusion:RhCcEe compatible blood transfusion can improve the levels of Hb,Hct and TBIL in patients with warm antibody AIHA,and does not increase the adverse reactions of blood transfusion,the safety is good.

关 键 词：自身免疫性溶血性贫血 配合性输血 RH血型系统 安全性 

分 类 号：R457.1[医药卫生—治疗学]