Hepatitis B core-related antigen:Are we near a treatment endpoint?  

作　　者：Tarana Gupta 

机构地区：[1]Medicine,Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences,Rohtak 124001,Haryana,India

出　　处：《World Journal of Gastroenterology》2022年第27期3532-3534,共3页世界胃肠病学杂志（英文版）

摘　　要：Different serological and virological markers in chronic hepatitis B patients guide staging of viral infection,and initiation and response to therapy.Due to the persistence of intrahepatic covalently closed circular DNA(cccDNA)in the hepatocyte nucleus,hepatitis B is not curable.Even after undetectable hepatitis B virus DNA levels,the persistence of hepatitis B surface antigen and novel markers such as hepatitis B core-related antigen(HBcrAg)indicate the persistence of intrahepatic cccDNA.In this study,HBcrAg levels at baseline and after 24 and 48 wk of antiviral therapy predicted hepatitis B e antigen seroconversion.Due to the poor sensitivity of assays and detectable levels in HBsAg-negative patients,the long-term utility of HBcrAg needs future research.

关 键 词：Hepatitis B core-related antigen Chronic hepatitis B Covalently closed circular DNA Hepatitis B e antigen seroconversion Hepatitis B virus DNA Pregenomic RNA 

分 类 号：R512.62[医药卫生—内科学]