Diffusion tensor imaging pipeline measures of cerebral white matter integrity: An overview of recent advances and prospects  

作　　者：Amanina Ahmad Safri Che Mohd Nasril Che Mohd Nassir Ismail Nurul Iman Nur Hartini Mohd Taib Anusha Achuthan Muzaimi Mustapha 

机构地区：[1]Department of Neurosciences,School of Medical Sciences,Universiti Sains Malaysia,Health Campus,Kubang Kerian 16150,Kelantan,Malaysia [2]Department of Radiology,School of Medical Sciences,Universiti Sains Malaysia,Health Campus,Kubang Kerian 16150,Kelantan,Malaysia [3]School of Computer Sciences,Universiti Sains Malaysia,11800 USM,Penang,Malaysia [4]Department of Neurosciences,Hospital Universiti Sains Malaysia,Kubang Kerian 16150,Kelantan,Malaysia

出　　处：《World Journal of Clinical Cases》2022年第24期8450-8462,共13页世界临床病例杂志

摘　　要：Cerebral small vessel disease(CSVD)is a leading cause of age-related microvascular cognitive decline,resulting in significant morbidity and decreased quality of life.Despite a progress on its key pathophysiological bases and general acceptance of key terms from neuroimaging findings as observed on the magnetic resonance imaging(MRI),key questions on CSVD remain elusive.Enhanced relationships and reliable lesion studies,such as white matter tractography using diffusion-based MRI(dMRI)are necessary in order to improve the assessment of white matter architecture and connectivity in CSVD.Diffusion tensor imaging(DTI)and tractography is an application of dMRI that provides data that can be used to non-invasively appraise the brain white matter connections via fiber tracking and enable visualization of individual patient-specific white matter fiber tracts to reflect the extent of CSVD-associated white matter damage.However,due to a lack of standardization on various sets of software or image pipeline processing utilized in this technique that driven mostly from research setting,interpreting the findings remain contentious,especially to inform an improved diagnosis and/or prognosis of CSVD for routine clinical use.In this minireview,we highlight the advances in DTI pipeline processing and the prospect of this DTI metrics as potential imaging biomarker for CSVD,even for subclinical CSVD in at-risk individuals.

关 键 词：Diffusion tensor imaging White matter Cerebral small vessel disease Pipeline processing TRACTOGRAPHY 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743[医药卫生—诊断学]