组织工程人工胆管的研究进展  

Research progress of tissue engineered artificial bile duct

作　　者：袁琪 徐雯 周文策[1] YUAN Qi;XU Wen;ZHOU Wence(The First School of Clinical Medicine of Lanzhou University,Lanzhou 730013;Zhangye People’s Hospital Affiliated to Hexi University,Zhangye,Gansu Province 734099)

机构地区：[1]兰州大学第一临床医学院,兰州730013 [2]河西学院附属张掖人民医院,甘肃张掖734099

出　　处：《北京生物医学工程》2022年第4期424-428,435,共6页Beijing Biomedical Engineering

基　　金：甘肃省卫生厅行业科研计划项目(GSWSKY2018-51);兰州市人才创新创业项目(2017-RC-37)资助。

摘　　要：胆管损伤后胆管狭窄是胆管疾病术后常见的并发症,其主要通过手术治疗,大部分患者术后胆道梗阻症状在短期内可以得到良好的改善,然而长期预后不容乐观。组织工程是一门新型技术,随着组织工程材料的不断发展,其在可吸收性、生物相容性及促组织再生等方面的优势使得人工胆管在胆管损伤后胆管狭窄修复中的应用成为可能。近年来生物3D打印技术的出现不但提高了制作人工胆管的精度,而且满足了按需打印的个体化差异要求,进一步推动了组织工程人工胆管的发展,使其成为未来胆管狭窄治疗的又一重要方式。Biliary stricture after bile duct injury is a common postoperative complication of bile duct disease,which is mainly treated by surgery.Most patients with postoperative biliary obstruction can get a good improvement in the short term,however the long-term prognosis is not optimistic.Tissue engineering is a new technology,with the continuous development of tissue engineering material.Its absorbability,biocompatibility,promoting tissue regeneration and other advantages make artificial bile duct in the application of bile duct stricture repair after injury of bile duct.In recent years,the emergence of biological 3D printing technology enhances the precision of making artificial bile duct and meets the requirement of individualized difference of on-demand printing,further promotes the development of tissue engineered artificial bile duct,and makes another important way for the treatment of bile duct stricture in the future.

关 键 词：组织工程 人工胆管 胆管狭窄 研究进展 生物3D打印 

分 类 号：R318.08[医药卫生—生物医学工程]