不同精神障碍患者神经内分泌异常率和糖调节受损率比较  

A Comparative Study of Neuroendocrine Abnormalities and Impaired Glucose Regulation Rates in Different Mental Deseases

作　　者：董再全[1] 郝燕妮[1] 沈晓玲 余建英[1] Dong Zaiquan;Hao Yanni;Shen Xiaoling;Yu Jianying(Mental Health Center of West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院心理卫生中心,成都610041

出　　处：《成都医学院学报》2022年第4期444-447,共4页Journal of Chengdu Medical College

基　　金：四川省科技厅重点研发项目(No:2019YFS0217)。

摘　　要：目的观察不同精神疾病患者伴发的神经内分泌异常和糖调节受损情况。方法选取2015年1月至2017年12月四川大学华西医院心理卫生中心收治的患有4种常见精神疾病之一的2306例患者为研究对象,其中焦虑障碍1017例(焦虑组),抑郁障碍978例(抑郁组),混合性焦虑抑郁障碍150例(焦虑抑郁组),双相情感障碍161例(双相情感组),采集4组一般人口学数据,检测其神经内分泌激素水平和血糖指标,并对结果进行对比分析。结果共2236例患者完成下丘脑垂体肾上腺(HPA)轴检测,异常831例(37.2%);抑郁组异常率最高,与焦虑组比较,差异有统计学意义(P<0.05)。共2305例患者完成下丘脑垂体甲状腺(HPT)轴检测,异常1007例(43.7%);抑郁组和双相情感组异常率较高,与焦虑组比较,差异有统计学意义(P<0.05)。共1898例患者完成血糖指标测试,其中糖调节受损607例(32.0%);各组间比较,差异无统计学意义(P>0.05)。结论4种精神疾病均伴随较高的神经内分泌异常率和糖调节受损率,需在临床工作中给予个体化的关注。Objective To explore the incidence of neuroendocrine abnormalities and impaired glucose regulation in patients with different mental diseases.Methods A total of 2306 patients suffered from one of the four common mental illnesses treated in the mental health center of West China Hospital of Sichuan University were selected as the research objects,including anxiety disorder(n=1017),depressive disorder(n=978),mixed anxiety-depressive disorder(n=150)and bipolar disorder(depression episode)(n=161).The general demographic data,neuroendocrine indicators and blood glucose indicators were collected and compared among the four groups.Results A total of 2236 patients accepted the detection of hypothalamic-pituitary-adrenal(HPA)axis indicators,with 831 abnormal cases(37.2%);Patients with depression had the highest abnormal rate,which was significantly different from that in the anxiety disorder group(P<0.05).A total of 2305 patients accepted the detection of hypothalamic-pituitary-thyroid(HPT)axis indicators,with 1007 abnormal cases(43.7%);Patients with depression and bipolar disorder shared the highest abnormal rate,which was significantly higher than that in the anxiety disorder group(P<0.05).A total of 1898 patients accepted the detection of blood glucose indicators,with 607 patients(32.0%)having impaired glucose regulation,but it showed no significant difference among the four groups(P>0.05).Conclusion The 4 mental diseases are accompanied with high rate of neuroendocrine abnormalities and impaired glucose regulation,implying that individualized attention is required in clinical work.

关 键 词：神经内分泌 糖调节受损 精神疾病 

分 类 号：R749.4[医药卫生—神经病学与精神病学]