男性不育患者精子参数与年龄和体质指数之间的关系  

The Relationship Between Male Sperm Parameters andAge and Body Mass Index

作　　者：胡哲英 郜宇 管瑞君 朱佳颖[1] 刘志强 陈丹朔 王霭明 HU Zheying;GAO Yu;GUAN Ruijun;ZHU Jiaying;LIU Zhiqiang;CHEN Danshuo;WANG Aiming(Department of Reproductive Medicine,Zhuozou City Hospital,Zhouzuo 072750,China;Obstetrics and Gynecology Reproductive Center of the Sixth Medical Center of PLA General Hospital,Beijing 100048,China)

机构地区：[1]河北省涿州市医院生殖医学科,河北涿州072750 [2]中国人民解放军第六医学中心妇产科生殖中心,北京100048

出　　处：《标记免疫分析与临床》2022年第6期913-917,共5页Labeled Immunoassays and Clinical Medicine

基　　金：吴阶平医学基金会资助项目(编号:320.6750.2021-19-3)。

摘　　要：目的通过对男性不育患者进行精子参数分析(SCD),探讨精子参数与患者年龄和体质指数(BMI)之间的关系。方法收集2019年1月至2021年12月在河北省涿州市医院生殖医学科就诊的195例男性不育患者精液样本,通过赛司SCA精液分析仪进行精液常规检测,采用精子染色质扩散试验(SCD)检测精子DNA碎片指数(DFI),分析精子参数与患者年龄和BMI之间的关系。结果与20~29岁患者相比,40岁以上患者精子浓度、总精子数和不动精子百分率(IM)指标显著提高(P<0.01、P<0.01、P=0.046);与30~39岁患者相比,40岁以上患者精子浓度和总精子数指标显著提高(P<0.01、P<0.01)。与20~29和30~39岁患者相比,40岁以上患者前向运动精子百分率(PR)显著降低(P=0.003、P=0.028)。随着患者体质指数的增加,与BMI<24、24~27.9患者相比,BMI>28患者精子DFI和IM显著提高(P=0.005、P=0.009;P=0.021、P=0.020);与BMI<24、24~27.9患者相比,BMI>28患者PR显著降低(P=0.008、P=0.021)。相关性分析表明,精子DFI与年龄、IM、BMI呈显著正相关(r=0.176,P<0.05;r=0.499,P<0.01;r=0.199,P<0.01),与PR呈显著负相关(r=-0.504,P<0.01)。结论男性精子参数与患者年龄、BMI具有一定相关性,随着男性患者年龄和体重的增加其精子参数呈现下降趋势,临床上评估男性生育能力时应关注患者年龄和BMI指数。Objective The relationship between sperm parameters and patient age and body mass index(BMI)was investigated by performing sperm parameter analysis(SCD)in male infertile patients.Methods The semen samples of 195 male infertile patients who were treated in the Department of Reproductive Medicine,Zhuozhou Hospital,Hebei Province from January,2019 to December,2021 were collected for the study,and these samples were routinely tested by the Semen SCA semen analyzer.Sperm chromatin diffusion test(SCD)was conducted to detect sperm DNA fragmentation index(DFI),and we analyzed the relationship between sperm parameters and patient age and BMI.Results Compared with patients aged 20-29,the sperm concentration,total sperm count and IM indexes of patients aged over 40 were significantly increased(P<0.01,P<0.01,P=0.046);Compared with patients aged 30-39,the sperm concentration and total sperm count of patients aged over 40 were significantly increased(P<0.01,P<0.01).Compared with patients aged 20-29 and 30-39,the percentage of forward motile sperm(PR)was significantly lower in patients over 40 years old(P=0.003,P=0.028).With the increase of patient’s body mass index,compared with patients with BMI<24 and 24-27.9,sperm DFI and percentage of immotile sperm(IM)in patients with BMI>28 were significantly increased(P=0.005,P=0.009;P=0.021,P=0.020);Compared with patients with BMI<24 and 24-27.9,patients with BMI>28 had significantly lower PR(P=0.008,P=0.021).Correlation analysis showed that sperm DFI was significantly positively correlated with age,IM,and BMI(r=0.176,P<0.05;r=0.499,P<0.01;r=0.199,P<0.01),and was significantly negatively correlated with PR(r=0.199,P<0.01).r=-0.504,P<0.01).Conclusion There is a certain correlation between male semen quality and patient age and BMI.With the increase of male patient age and weight,the semen quality shows a downward trend,suggesting that during clinical evaluation of male fertility,clinicians should pay attention to patient’s age and BMI index.

关 键 词：不育患者 精子DNA碎片指数(DFI) 年龄 体质指数 相关性 

分 类 号：R698.2[医药卫生—泌尿科学]