非瓣膜性心房颤动与同型半胱氨酸的相关性及中医证型分布特点研究  

Relationship between Non-valvular Atrial Fibrillation,Homocysteine and Characteristics of TCM Syndrome

作　　者：崔景润 李军[1] 吴旸[2] CUI Jingrun;LI Jun;WU Yang(Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;不详)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学东方医院,北京100029

出　　处：《中西医结合心脑血管病杂志》2022年第14期2508-2512,共5页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨非瓣膜性心房颤动病人中医证型分布特点及非瓣膜性心房颤动与同型半胱氨酸(Hcy)的相关性。方法纳入2016年3月1日—2017年3月31日于北京中医药大学东方医院心内科住院的非瓣膜性心房颤动病人118例,并遵循年龄分层原则,按照入院先后顺序连续选取2016年8月1日—2016年9月30日北京中医药大学东方医院心内科病房70例非心房颤动病人作为对照组。应用“非瓣膜性心房颤动病人中医证型量表”采集病人临床信息、中医四诊信息及辅助检查资料,并进行相关性分析。结果与对照组比较,非瓣膜性心房颤动组合并高血压、脑血管病比例升高,差异均有统计学意义(P<0.05)。对118例非瓣膜性心房颤动病人中医证型分布特点分析发现,非瓣膜性心房颤动病人中医证型分布为气虚血瘀证(59例)>气阴两虚证(24例)>痰瘀互阻证(14例)>阴虚火旺证(7例)>心血不足证(5例)>水饮凌心证(4例)>痰火扰心证(3例)>心阳不振证(2例)。与对照组比较,非瓣膜性心房颤动组左心房内径(LAD)增大,差异有统计学意义(P<0.05)。与对照组比较,非瓣膜性心房颤动组血浆Hcy升高,差异有统计学意义(P<0.05)。对85例Hcy升高(>15μmol/L)的非瓣膜性心房颤动病人Hcy与LAD进行相关性分析,结果表明,Hcy增高与LAD无相关性(P>0.05)。对41例病程超过1年的Hcy升高的非瓣膜性心房颤动病人Hcy与LAD进行相关性分析,提示二者之间无明显相关性(P>0.05)。结论高血压、脑血管病常与非瓣膜性心房颤动合并,互为因果;气虚血瘀证是非瓣膜性心房颤动病人的最常见中医证型。Objective To explore the characteristics of traditional Chinese medicine(TCM)syndromes in patients with non-valvular atrial fibrillation and the correlation between non-valvular atrial fibrillation and homocysteine(Hcy).Methods One hundred and eighteen patients with non-valvular atrial fibrillation were included,and 70 patients with non-atrial fibrillation in the Department of Cardiology,Dongfang Hospital,Beijing University of Chinese Medicine from August 1,2016 to September 30,2016 were selected as control group followed the principle of age stratification."Non-valvular Atrial Fibrillation Patient TCM Syndrome Type Scale"was used to collect patient clinical information,four TCM diagnosis information,and auxiliary examination data,and the correlation analysis was conducted.Results Compared with control group,the proportion of patients with non-valvular atrial fibrillation combined with hypertension and cerebrovascular disease was high,and the difference was statistically significant(P<0.05).The distribution of TCM syndromes in 118 patients with NVAF was Qi deficiency and blood stasis syndrome(59 cases),Qi and Yin deficiency syndrome(24 cases),phlegm stasis mutual blocking syndrome(14 cases),Yin-deficiency and fire-excess syndrome(7 cases),deficiency of heart-blood syndrome(5 cases),water-drinking heart syndrome(4 cases),phlegm-fire disturbing heart(3 cases),heart Yang deficiency syndrome(2 cases).Compared with control group,the left atrial diameter(LAD)of patients with non-valvular atrial fibrillation was high,and the difference was statistically significant(P<0.05).Compared with control group,the plasma Hcy of 118 patients with non-valvular atrial fibrillation was high,and the difference was statistically significant(P<0.05).The 85 patients with non-valvular atrial fibrillation should elevated Hcy(>15μmol/L)but there was no significant positive correlation between Hcy and LAD(P>0.05).Forty-one patients with non-valvular atrial fibrillation with elevated Hcy over 1 year were tested again and showed there was no

关 键 词：非瓣膜性心房颤动 同型半胱氨酸 中医证型 相关性 左心房内径 

分 类 号：R259[医药卫生—中西医结合]