Ghrelin对心血管系统的保护作用及其机制  

Protective effect of Ghrelin on cardiovascular system and its mechanism

作　　者：王帆(综述)[1] 吴梓璇 魏来 张晓卉(审校)[1] WANG Fan;WU Zixuan;WEI Lai;ZHANG Xiaohui(Department of Cardiology,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院心内科,哈尔滨150001

出　　处：《临床与病理杂志》2022年第7期1745-1750,共6页Journal of Clinical and Pathological Research

基　　金：黑龙江省自然科学基金(LH2020H034);黑龙江省博士后科研启动金(LBH-Q18080);哈尔滨医科大学附属第一医院院杰出青年基金(HYD2020JQ0005);哈尔滨医科大学附属第一医院院基金(2019M08)。

摘　　要：胃饥饿素(Ghrelin)是一种含有28个氨基酸残基的多肽,是生长激素促分泌素受体的特异性配体。Ghrelin参与控制食欲和能量平衡,调节碳水化合物和脂质代谢、细胞增殖和凋亡,还可以参与胃肠道、支气管、肺和免疫系统的功能调节。近年来研究发现Ghrelin可以通过抗心肌细胞凋亡、调节自噬、抗炎、抗心肌纤维化、调节自主神经系统及血管保护等方面发挥对心血管系统的保护作用。Ghrelin,a polypeptide with 28 amino acid residues,is a specific ligand of growth hormone secretagogue receptor.Ghrelin is involved in controlling appetite and energy balance,regulating carbohydrate and lipid metabolism,cell proliferation and apoptosis,and regulating the function of gastrointestinal tract,bronchus,lung,and immune system.In recent years,it has been found that Ghrelin can protect cardiovascular system through anticardiomyocyte apoptosis,regulation of autophagy,anti-inflammation,anti-myocardial fibrosis,regulation of autonomic nervous system,and vascular protection.

关 键 词：胃饥饿素 心血管系统 凋亡 自噬 

分 类 号：R54[医药卫生—心血管疾病]