甘肃省严重急性呼吸系统综合征冠状病毒2 Delta变异株感染患者的临床特征分析  

Clinical characteristics of patients with SARS-CoV-2 Delta variant infection in Gansu Province

作　　者：魏继芳 岳红梅[1,2] 刘南玉[1] 宋佩佩 谢莹莹 王嘉琪 魏雅倩 WEI Jifang;YUE Hongmei;LIU Nanyu;SONG Peipei;XIE Yingying;WANG Jiaqi;WEI Yaqian(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;不详)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院呼吸与危重症医学科

出　　处：《山东医药》2022年第23期1-5,共5页Shandong Medical Journal

基　　金：甘肃省科技重大专项[甘科计(2020)1号-25]。

摘　　要：目的通过与严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2)野生株感染者比较,总结甘肃省SARSCoV-2 Delta变异株感染患者的临床特征。方法选择甘肃省确诊的SARS-CoV-2 Delta变异株感染患者141例(变异株组)和野生株感染患者88例(野生株组),回顾性收集其临床资料并进行比较。结果变异株组合并高血压及接种疫苗比例均高于野生株组(P均<0.05),两组均以轻型及普通型居多,其他一般资料比较P均>0.05。变异株组发热、乏力、肌肉酸痛、胸闷气短比例均低于野生株组,咽痒比例高于野生株组(P均<0.05)。变异株组白细胞(WBC)<4.0×10^(9)/L、血小板(PLT)<100×10^(9)/L、谷氨酰转肽酶(GGT)>50.0 U/L、乳酸脱氢酶(LDH)>240.0 U/L、血尿素氮(BUN)>7.1 mmol/L、国际标准化比率(INR)>1.13的比例均低于野生株组,天门冬氨酸氨基转移酶(AST)>40U/L的比例均高于野生株组(P均<0.05);两组丙氨酸氨基转移酶(ALT)、血肌酐(Cr)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、降钙素原(PCT)、C反应蛋白(CRP)比较P均>0.05。变异株组胸部CT异常、双侧病变、3个及以上肺叶病变的比例均低于野生株组(P均<0.05)。变异株组给予干扰素、利巴韦林、洛匹那韦/利托那韦、抗生素、糖皮质激素、免疫球蛋白、血必净、阿比多尔片、吸氧治疗的比例均低于野生株组(P均<0.05)。变异株组给予俯卧位通气、抗凝、中和抗体、胸腺法新、保肝治疗的比例均高于野生株组(P均<0.05)。野生株组出院时35例(53.0%)淋巴细胞未恢复到正常水平,两组淋巴细胞恢复时间、肺部病灶吸收时间、核酸转阴时间比较差异均无统计学意义(P均>0.05)。变异株组血氧饱和度(SaO_(2))恢复时间短于野生株组,住院时间长于野生株组(P均<0.05)。野生株组死亡2例(2.3%),变异株组死亡0例,两组比较P>0.05。结论相较于SARS-CoV-2野生株感染�Objective To summarize the clinical characteristics of patients with severe acute respiratory syndrome corona virus 2(SARS-CoV-2) Delta variant infection by comparing with patients with wild strain infection in Gansu Province.Methods Totally 141 patients diagnosed with Delta variant infection(variant group) and 88 patients with COVID-19(wild strain group) in Gansu Province were selected,and their clinical data were retrospectively collected and compared.Results The proportion of patients with hypertension and vaccination was higher in the variant group than in the wild strain group(P<0.05).Most of the two groups were mild and common types,and there were no statistically significant differences in the other general data(all P>0.05).The percentages of fever,fatigue,muscle soreness,chest tightness and shortness of breath in the variant group were lower than those in the wild group,and the proportion of sore throat was higher than that in the wild group(all P<0.05).The proportions of white blood cells(WBC) <4.0×10^(9)/L,platelets(PLT) <100×10^(9)/L,glutamyl transpeptidase(GGT)>50.0 U/L,lactate dehydrogenase(LDH)>240.0 U/L,blood urea nitrogen(BUN)>7.1 mmol/L,and international normalized ratio(INR)>1.13 were all lower in the variant group than in the wild strain group(all P<0.05);the percentage of aspartate aminotransferase(AST)>40 U/L was higher than that of the wild strain group(P<0.05).No significant differences were found in the alanine aminotransferase(ALT),blood creatinine(Cr),creatine kinase(CK),creatine kinase isoenzyme(C.K-MB),activated partial thromboplastin time(APTT),prothrombin time(PT),calcitoninogen(PCT),or C-reactive protein(CRP) between these two groups(all P>0.05).The proportions of abnormal chest CT,bilateral lesions,and three or more lobar lesions were significantly lower in the variant group than in the wild strain group(all P<0.05).The proportions of treatments with interferon,ribavirin,lopinavir/ritonavir,antibiotics,glucocorticoids,immunoglobulins,hemopexin,Abidor tablets,and oxygen were lower

关 键 词：新型冠状病毒肺炎 野生株 Delta变异株 临床特征 预后 

分 类 号：R563.1[医药卫生—呼吸系统]