Mesenchymal stem cells and cell-free preparations for treating atopic dermatitis  

作　　者：TRINIDAD MONTERO-VILCHEZ MANUEL SANCHEZ-DIAZ CAROLINA MONTERO-VILCHEZ ALVARO SIERRA-SANCHEZ SALVADOR ARIAS-SANTIAGO 

机构地区：[1]Dermatology Department,Virgen de las Nieves University Hospital,Granada,Spain [2]Instituto de Investigación Biosanitaria Granada,Granada,Spain [3]Pharmacy Department,Virgen de las Nieves University Hospital,Granada,Spain [4]Dermatology Department,Faculty of Medicine,University of Granada,Granada,Spain

出　　处：《BIOCELL》2022年第11期2363-2367,共5页生物细胞（英文）

摘　　要：Atopic dermatitis(AD)is a chronic cutaneous inflammatory disease caused by an interaction between genetic,immune and epidermal barrier factors.Several treatments can be used to treat this disease but there are patients that do not respond to actual drugs.So,there is a need to develop effective therapies for AD.Mesenchymal stem cells(MSCs)are non-hematopoietic multipotent adult progenitor cells with immunomodulatory power and self-regenerating capacity to repair tissue damage,so they could be a potential effective treatment for AD.MSCs-Conditioned Medium(CM)and MSCs-exosomes are cell-free preparation with molecules secreted by stem cells that could be also beneficial for AD.This viewpoint reviews the actual development of MSCs,MSCs-CM and MSCs-exosomes for treating patients with AD.

关 键 词：Atopic dermatitis Conditioned medium DERMATOLOGY Mesenchymal stem cells Stem cells 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]