Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR):A critical overview on the most promising applications of molecular scissors in oral medicine  

作　　者：MARCO TATULLO LUISA LIMONGELLI ROSA MARIA MARANO ALESSANDRA VALLETTA ANGELA TEMPESTA SANDRO RENGO 

机构地区：[1]Department of Basic Medical Sciences,Neurosciences and Sense Organs,University of Bari Aldo Moro,Bari,74124,Italy [2]Department of Interdisciplinary Medicine,University of Bari Aldo Moro,Bari,74124,Italy [3]Marrelli Health-Tecnologica Research Institute,Biomedical Section,Stem Cells and Medical Genetics Units,Crotone,88900,Italy [4]Department of Neurosciences,Reproductive and Odontostomatological Sciences,University of Naples Federico II,Naples,80131,Italy

出　　处：《BIOCELL》2022年第8期1837-1842,共6页生物细胞（英文）

摘　　要：The scientific community is continuously working to translate the novel biomedical techniques into effective medical treatments.CRISPR-Cas9 system(Clustered Regularly Interspaced Short Palindromic Repeats-9),commonly known as the“molecular scissor”,represents a recently developed biotechnology able to improve the quality and the efficacy of traditional treatments,related to several human diseases,such as chronic diseases,neurodegenerative pathologies and,interestingly,oral diseases.Of course,dental medicine has notably increased the use of biotechnologies to ensure modern and conservative approaches:in this landscape,the use of CRISPR-Cas9 system may speed and personalize the traditional therapies,ensuring a good predictability of clinical results.The aim of this critical overview is to provide evidence on CRISPR efficacy,taking into specific account its applications in oral medicine.

关 键 词：Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR) DENTISTRY Stem cells 

分 类 号：Q78[生物学—分子生物学]