A mini-review on pharmacological effects of ginsenoside Rb3,a marked saponin from Panax genus  

作　　者：WEI LI YUEYANG DUAN XIAOTONG YAN XIANGXIANG LIU MEILING FAN ZI WANG 

机构地区：[1]College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun,130118,China [2]National&Local Joint Engineering Research Center for Ginseng Breeding and Development,Changchun,130118,China [3]Maternity Diagnosis&Treatment Center,The Affiliated Hospital of Changchun University of Chinese Medicine,Changchun,130021,China

出　　处：《BIOCELL》2022年第6期1417-1423,共7页生物细胞（英文）

基　　金：This work was funded by the grant of Jilin Science&Technology Development Plan(No.20200301037RQ).

摘　　要：Ginsenoside Rb3(G-Rb3)is one of the primary active compounds isolated from Panax ginseng Meyer,which belongs to protopanaxadiol ginsenosides(PPD).Based on the structure-activity relationship(SAR)of ginsenosides,the pentose structure of G-Rb3 limited itself to possess more pharmacological activity to a certain extent.However,pharmacokinetics show that G-Rb3 is processed through deglycosylation in the intestinal tract and converted into more active rare saponins,such as Compound K,F2,etc.A series of studies focused on neuroprotection and the cardiovascular system demonstrating its therapeutic potentials,which was achieved by diminishing oxidative stress and apoptosis.Therefore,more systematic and in-depth studies are needed to complete the pharmaceutical value and to promote its clinical applications.This article highlights the multiple pharmacological effects and mechanisms of G-Rb3 and prospects for its development.

关 键 词：Ginsenoside Rb3 Pharmacological effects Review Signaling pathway 

分 类 号：R28[医药卫生—中药学]