厚朴及其有效成分厚朴酚与和厚朴酚对口腔感染性疾病防治作用的研究进展  

Progress in Preventive and Therapeutic Effects Of Cortex Magnoliae Officinalis and Its Effective Components Magnolol and Honokiol on Oral Infectious Diseases

作　　者：张明发[1] 沈雅琴[1] ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《抗感染药学》2022年第4期461-466,共6页Anti-infection Pharmacy

基　　金：国家自然科学基金资助项目(编号:39370838)。

摘　　要：厚朴及其有效成分厚朴酚与和厚朴酚具有广谱的抗病毒、抗真菌、抗球菌和抗杆菌作用。针对口腔感染性疾病,通过局部使用厚朴提取物、厚朴酚与和厚朴酚,可产生抗氧化和抗炎作用,从而保护口腔上皮细胞和抑杀口腔致病菌,进而防治龋齿和牙周炎的发生和发展,阻滞牙槽骨的骨吸收而防治牙松动。该文综述了厚朴及其有效成分厚朴酚与和厚朴酚对口腔感染性疾病防治作用,并对其研究进展做了分析。Cortex magnoliae officinalis and its effective components magnolol and honokiol have broad-spectrum antiviral, antifungal, anticoccidial and antibacterial effects. For oral infectious diseases, the topical application of cortex magnoliae officinalis extract, magnolol and honokiol can produce antioxidative and anti-inflammatory effects to protect oral epithelial cells and inhibit oral pathogenic bacteria, thus preventing the occurrence and development of dental caries and periodontitis, and preventing dental loosening by blocking bone resorption of alveolar bone. This paper reviews the preventive and therapeutic effects of cortex magnoliae officinalis and its effective components magnolol and honokiol on oral infectious diseases, and analyzes the research progress.

关 键 词：厚朴 厚朴酚 和厚朴酚 口腔疾病 

分 类 号：R961[医药卫生—药理学]