四川省部分地区肠道病毒71型灭活疫苗保护效果的配对病例对照研究  

A matched case-control study on the vaccine efficacy(VE)of the enterovirus type 71 vaccine of inactivated in some areas of Sichuan Province

作　　者：黄小梅 林雪倩[2] 刘伦光[3] 敬维[2] 蓝羲 HUANG Xiao-mei;LIN Xue-qian;LIU Lun-guang;JING Wei;LAN Xi(Panzhihua Center for Disease Control and Prevention,Panzhihua 617000,Sichuan Province,China;Nanchong Center for Disease Control and Prevention,Nanchong 63700,Sichuan Province,China;Sichuan Center for Disease Control and Prevention,Chengdu 610041,Sichuan Province,China)

机构地区：[1]攀枝花疾病预防控制中心,四川攀枝花617000 [2]南充市疾病预防控制中心,四川南充637000 [3]四川省疾病预防控制中心,成都610041

出　　处：《预防医学情报杂志》2022年第7期959-964,共6页Journal of Preventive Medicine Information

摘　　要：目的评价2017—2020年四川省部分地区6~59月龄儿童肠道病毒71型(EV-A71)灭活疫苗肠道病毒71型疫苗的保护效果(VE)。方法从《中国疾病预防控制信息系统》和《四川省免疫规划信息管理系统》中获取2017—2020年四川省部分市、县6~59月龄儿童个案,采用检测阴性设计的1∶2配对病例对照研究方法进行调查分析。结果病例组纳入308例,对照组匹配616例,全程两剂次EV-A71灭活疫苗接种VE(93%,95%CI:87%~96%)高于单剂次接种EV-A71灭活疫苗的VE(78%,95%CI:51%~90%);24~59月龄组单剂次接种EV-A71灭活疫苗的VE(92%,95%CI:26%~99%)高于6~23月龄组(72%,95%CI:33%~88%);接种EV-A71灭活疫苗后到发病,不同时间间隔,VE值不同,最后1次接种EV-A71灭活疫苗到病例发病的时间间隔为12~17月的疫苗保护率最高。结论接种EV-A71灭活疫苗可有效预防EV-A71感染的手足口病,全程两剂次接种的保护效果优于单剂次接种。Objective To evaluate the vaccine efficacy(VE)of the inactivated Enterovirus type 71(EV-A71)vaccine for children aged 6-59 months in some areas of Sichuan Province from 2017 to 2020.Methods Cases of children aged 6 to 59 months were obtained in some cities and counties of Sichuan Province from 2017 to 2020 from the“China Disease Prevention and Control Information System”and“Sichuan Province Immunization Program Information Management System”,a 1∶2 matched case-control study method with a negative test design was used for investigation and analysis.Results Overall vaccine efficacy was estimated to be 93%[95%CI:87%-96%]for fully vaccinated children and 78%[95%CI:51%~90%]for partially vaccinated children.The vaccine efficacy for partial vaccination was 92%[95%CI:26%-99%]in children aged 24-59 months and 72%[95%CI:33%-88%]in children aged 6-23 months.Conclusions The Inactivated Enterovirus type 71(EV-A71)vaccine was effective in preventing hand,foot,and mouth disease due to EV-A71 virus infection for children aged 6-59 months.

关 键 词：EV-A71灭活疫苗 疫苗保护效果(VE) 手足口病 检测阴性设计病例对照 

分 类 号：R186[医药卫生—流行病学]