血压正常孕妇和子痫前期孕妇的维生素D、钙和磷水平比较以及相关性分析  

Comparison and correlation analysis of vitamin D,calcium and phosphorus levels between normal blood pressure pregnant women and preeclampsia pregnant women

作　　者：张雪[1] 杜鹃[1] ZHANG Xue;DU Juan(Department of Obstetrics and Gynecology,Shengjing Hospital affiliated to China Medical University,Shenyang 110004,Liaoning Province,China)

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004

出　　处：《中国临床药理学杂志》2022年第14期1575-1578,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的比较血压正常孕妇和子痫前期孕妇的维生素D、钙和磷水平并分析其相关性。方法选取2018年至2020年在院收治的80例孕妇作为研究对象,根据病情将孕妇分为2组:对照组40例,试验组40例,对比2组孕妇的血清钙、磷和25-羟基维生素D水平,对比重度子痫前期孕妇和其他子痫前期孕妇的血清钙、磷和25-羟基维生素D水平,采用Pearson相关系数分析子痫前期孕妇25-羟基维生素D与血清钙、磷水平的相关性,比较2组孕妇的妊娠结局。结果对照组孕妇的血清钙、磷和25-羟基维生素D水平分别为(2.34±0.21)mmol·L^(-1),(1.21±0.38)mmol·L^(-1)和(50.55±4.05)nmol·L^(-1);试验组孕妇的血清钙、磷和25-羟基维生素D水平分别为(1.51±0.19)mmol·L^(-1),(0.86±0.11)mmol·L^(-1)和(40.26±3.49)nmol·L^(-1);其他子痫前期孕妇的血清钙、磷和25-羟基维生素D水平分别为(1.49±0.16)mmol·L^(-1),(0.85±0.15)mmol·L^(-1)和(39.95±2.80)nmol·L^(-1);重度子痫前期孕妇的血清钙、磷和25-羟基维生素D水平分别为(1.44±0.02)mmol·L^(-1),(0.72±0.02)mmol·L^(-1)和(36.52±1.48)nmol·L^(-1);对照组和试验组孕妇的新生儿5 min Apgar评分分别为(9.65±0.48)和(8.30±1.04)分;对照组孕妇的新生儿早产、新生儿窒息、胎儿窘迫的发生率分别为5.00%(2/40),2.50%(1/40)和0.00%(0/40);试验组孕妇的新生儿早产、新生儿窒息、胎儿窘迫的发生率分别为22.50%(9/40),17.50%(7/40)和10.00%(4/40);对照组孕妇与试验组孕妇相比,上述指标差异均有统计学意义(均P<0.05)。经Pearson相关性分析显示,子痫前期孕妇的25-羟基维生素D水平与血清钙、磷水平呈正相关关系(均P<0.05)。结论子痫前期孕妇的维生素D、钙和磷水平明显低于血压正常孕妇,且维生素D、钙和磷水平也随着子痫前期孕妇病情的加重而逐渐降低,三者可作为妊娠期预测子痫前期及其严重程度的指标。The levels of vitamin D,calcium and phosphorus in pregnant women with normal blood pressure and preeclampsia were compared and analyzed.Methods A total of 80 pregnant women admitted to the hospital from 2018 to 2020 were selected as the research objects.According to their conditions,pregnant women were divided into two groups,including 40 cases of control group and 40 cases of treatment group.The serum calcium,phosphorus and 25-hydroxyvitamin D levels of pregnant women in the two groups were compared.The serum calcium,phosphorus and 25-hydroxyvitamin D levels of pregnant women with severe preeclampsia and other preeclampsia were compared.Pearson correlation coefficient was used to analyze the correlation between 25-hydroxyvitamin D and serum calcium and phosphorus levels of pregnant women with preeclampsia,and the pregnancy outcomes of the two groups were compared.Results The serum levels of calcium,phosphorus and 25-hydroxyvitamin D in control group were(2.34±0.21)mmol·L^(-1),(1.21±0.38)mmol·L^(-1) and(50.55±4.05)nmol·L^(-1),respectively.The serum levels of calcium,phosphorus and 25-hydroxyvitamin D in treatment group were(1.51±0.19)mmol·L^(-1),(0.86±0.11)mmol·L^(-1) and(40.26±3.49)nmol·L^(-1),respectively.The serum levels of calcium,phosphorus and 25-hydroxyvitamin D in other preeclampsia were(1.49±0.16)mmol·L^(-1),(0.85±0.15)mmol·L^(-1) and(39.95±2.80)nmol·L^(-1),respectively.The serum levels of calcium,phosphorus and 25-hydroxyvitamin D in pregnant women with severe preeclampsia were(1.44±0.02)mmol·L^(-1),(0.72±0.02)mmol·L^(-1) and(36.52±1.48)nmol·L^(-1),respectively.The Apgar scores at 5 min in the control group and the treatment group were(9.65±0.48)and(8.30±1.04)points,respectively.The incidence of premature birth,neonatal asphyxia and fetal distress in control group was 5.00%(2/40),2.50%(1/40)and 0.00%(0/40),respectively.The incidence of premature birth,neonatal asphyxia and fetal distress in treatment group was 22.50%(9/40),17.50%(7/40)and 10.00%(4/40),respectively.Compared with

关 键 词：血压 子痫前期 维生素D 血清钙 血清磷 

分 类 号：R71[医药卫生—妇产科学]