儿童造血干细胞移植后常见肺部非感染性并发症的研究现状  

Current research status of common pulmonary non-infectious complications in children after hematopoietic stem cell transplantation

作　　者：高雨 王红美[2] Gao Yu;Wang Hongmei(Department of Pediatric Hematology,Shandong Provincial Qianfoshan Hospital,Shandong First Medical University,Jinan 250014,Shandong Province,China;Department of Pediatric Hematology,First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Jinan 250014,Shandong Province,China)

机构地区：[1]山东第一医科大学,山东省千佛山医院小儿血液科,济南250014 [2]山东第一医科大学第一附属医院(山东省千佛山医院)小儿血液科,济南250014

出　　处：《国际输血及血液学杂志》2022年第3期213-221,共9页International Journal of Blood Transfusion and Hematology

基　　金：白求恩·医学科学研究基金(B20103AN)。

摘　　要：近年来,儿童造血干细胞移植(HSCT)技术发展迅速,疗效逐年提高。肺部并发症是影响HSCT患儿预后的重要因素。儿童HSCT术后肺部并发症发生率为25%~50%,包括感染性及非感染性并发症。常见的移植后早、中期肺部非感染性并发症包括弥漫性肺泡出血(DAH)、植入综合征(ES)、血栓性微血管病(TMA)等,常见晚期并发症包括闭塞性细支气管炎综合征(BOS)等。笔者拟就患儿接受HSCT后常见肺部非感染性并发症的临床特点、危险因素、发病机制及治疗进展进行阐述,旨在为临床医师诊治该类疾病提供思路。In recent years,the technology of pediatric hematopoietic stem cell transplantation(HSCT)has developed rapidly,and efficacy has been gradually improved.Pulmonary complications significantly affect prognosis of children after HSCT.Incidences of pulmonary complications in children after HSCT are 25%-50%,involving infectious and non-infectious complications.Pulmonary non-infectious complications in the early and middle stages in children after HSCT usually include diffuse alveolar hemorrhage(DAH),engraftment syndrome(ES)and thrombotic microangiopathies(TMA).Bronchiolitis obliterans syndrome(BOS)is the common complication in the late stage after HSCT.This article intends to summarize the clinical characteristics,risk factors,pathogenesis and treatment progress of common pulmonary non-infectious complications of children undergoing HSCT,aiming to provide some reference for clinicians in diagnosis and treatment of these diseases.

关 键 词：造血干细胞移植 血栓性微血管病 闭塞性细支气管炎 儿童 肺部并发症 非感染性并发症 弥漫性肺泡出血 植入综合征 

分 类 号：R457.7[医药卫生—治疗学] R725.6[医药卫生—临床医学]