共信号分子CD160的结构功能、信号网络及其在人类疾病中作用的研究新进展  

Research advances on structure and function,signaling network,and roles in human diseases of co-signaling molecule CD160

作　　者：朱佳琳 刘绘绘 董玉君[1] Zhu Jialin;Liu Huihui;Dong Yujun(Department of Hematology,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院血液内科,北京100034

出　　处：《国际输血及血液学杂志》2022年第3期222-228,共7页International Journal of Blood Transfusion and Hematology

基　　金：北京大学第一医院科研种子基金(2019SF02)。

摘　　要：糖基磷脂酰肌醇(GPI)锚定的跨膜糖蛋白CD160作为免疫球蛋白超家族(IgSF)成员,可通过与自然杀伤(NK)细胞和T细胞作用影响机体免疫功能。根据是否存在免疫球蛋白(Ig)结构域和细胞膜表面锚定方式的差异,CD160分子可被分为4种异构体。CD160与其配体疱疹病毒进入介质(HVEM)形成的CD160-HVEM复合体是IgSF和肿瘤坏死因子受体超家族(TNFRSF)间直接相互作用的特例,并且根据靶细胞的不同,CD160-HVEM复合体可产生共刺激或共抑制信号,从而调控免疫应答。HVEM作为一个信号分子开关,与不同信号通路相互作用,形成HVEM网络,在免疫应答中发挥重要作用。现有研究结果表明,CD160在多种恶性肿瘤、慢性病毒感染性疾病、自身免疫性疾病、实体器官移植后宿主抗移植物反应等疾病中均发挥作用。笔者对CD160的结构及特点、CD160异构体、CD160-HVEM复合体、HVEM网络,以及CD160在人类疾病中作用的研究新进展进行阐述。Glycosylphosphatidylinositol(GPI)-anchored transmembrane glycoprotein CD160 is a member of the immunoglobulin(Ig)superfamily(IgSF).CD160 can affect the normal function of the immune system through different effects on natural killer(NK)cells and T cells.Four isomers of CD160 have been identified,according to the presence of Ig domains and pattern anchored to cell membranes.CD160 and its ligand herpesvirus entry mediator(HVEM)form the CD160-HVEM complex,which is a particular case of direct interaction between,IgSF and tumor necrosis factor receptor super family(TNFRSF).Depending on the target cell,the CD160-HVEM complex can produce co-stimulatory or co-inhibitory signals that regulate the immune response.HVEM is also referred to as a consignaling"molecular switch",interacting with different signaling pathways forming a network,which has a profound function in the immune system.Existing studies have shown that CD160 plays a role in various diseases including cancers,chronic viral infection diseases,autoimmune diseases,host versus graft reaction after solid organ transplantation,and other diseases.This article provides a summary of the structure,isoforms of CD160,CD160-HVEM complex,network of HVEM,and role of CD160 in human diseases.

关 键 词：抗原 CD160 糖基磷脂酰肌醇类 信号传导 TNFRSF14蛋白 人类 BTLA蛋白 人类 

分 类 号：R392[医药卫生—免疫学]