CD8^(+)T细胞应答在慢性乙肝肝损伤中的作用和机制  

The role of CD8^(+)T cell response in the liver injury during chronic hepatitis B

作　　者：王粤 葛名扬 卢长川 吕璇 辛小娟[1] 王靖雪 WANG Yue;GE Mingyang;LU Changchuan;LYU Xuan;XIN Xiaojuan;WANG Jingxue(Department of Infectious Diseases,First Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China;Institute of Immunology,Army Medical University,Chongqing 400038,China)

机构地区：[1]重庆医科大学附属第一医院感染科,400010 [2]陆军军医大学基础医学院免疫学教研室,重庆400038

出　　处：《免疫学杂志》2022年第8期733-736,共4页Immunological Journal

基　　金：重庆市自然科学基金(cstc2021jcyj-msxmX0657);重庆市科卫联合医学科研重点项目(2019ZDXM004)。

摘　　要：CD8+T细胞应答在慢性乙肝感染中具有至关重要的地位。有缺陷的HBV特异性CD8^(+)T细胞应答常常导致感染控制不力,而旁观者CD8^(+)T细胞应答和肝内浸润则可能通过抗原不依赖的方式促进肝细胞发生损伤。肝血窦内的血小板聚集促进CD8^(+)T细胞锚定于肝内,使CD8^(+)T细胞在肝内缓慢爬行,识别抗原,导致肝细胞特异性或非特异性损伤。本文综述了近来肝内HBV特异性和旁观者CD8^(+)T细胞应答在慢性乙肝相关肝损伤发生中的研究进展。The CD8^(+)T cell responses play a crucial role in chronic hepatitis B infection.Defective HBVspecific CD8^(+)T cell responses often lead to ineffective control of HBV infection,whereas bystander CD8^(+)T cell responses and intrahepatic infiltration may contribute to hepatocyte injury.Platelet aggregation within the hepatic sinuses anchors CD8^(+)T cells within the liver,allowing CD8^(+)T cells to crawl slowly in the liver and recognize antigens,which subsequently leads to hepatocyte death in antigen-dependent or independent manner.This review summarizes the activation mechanisms of intrahepatic HBV-specific CD8^(+)T cell and roles of bystander CD8^(+)T cell responses in chronic hepatitis B-related liver damage.

关 键 词：慢性乙肝感染 CD8^(+)T细胞应答缺陷 肝损伤 旁观者CD8^(+)T活化 

分 类 号：R392.3[医药卫生—免疫学]