淋巴毒素受体信号介导组织再生的研究进展  

Research progress in tissue regeneration mediated by lymphotoxin receptor signal

作　　者：胡诤贇 史建伟 周国平[1] HU Zhengyun;SHI Jianwei;ZHOU Guoping(Department of Pediatrics,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029;Department of Pediatrics,Shanghai Songjiang District Central Hospital,Shanghai 201600;Department of Neurosurgery,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210024,China)

机构地区：[1]南京医科大学第一附属医院儿科,江苏南京210029 [2]上海市松江区中心医院儿科,上海201600 [3]南京医科大学附属脑科医院神经外科,江苏南京210024

出　　处：《南京医科大学学报（自然科学版）》2022年第7期1036-1042,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基因(81970579)。

摘　　要：淋巴毒素α、β及其受体(lymphotoxin alpha receptor、lymphotoxin beta receptor,LTAR、LTBR)属于肿瘤坏死因子超家族,LTBR信号在淋巴器官发育、维持完整的淋巴结构、诱导抗病原体的免疫反应、介导器官组织的再生和肿瘤发生发展的过程中发挥了重要作用。LTBR信号主要通过非经典/经典核转录因子-κB(nuclear transcription factor-kappa B,NF-κB)通路的信号转导来诱导趋化因子和黏附分子的分泌,从而促进细胞增殖与分化。LTBR信号不仅在自身免疫系统疾病中发挥作用,而且通过不同模型展现了其抗癌与促癌的双重功效。本文将重点围绕LTBR信号在多种器官生长发育和组织受损后的再生中所发挥的作用进行综述,以期为再生医学研究提供新的视角。Lymphotoxinα,βand its receptor(LTAR,LTBR)belong to the tumor necrosis factor superfamily.LTBR signaling has a variety of physiological functions.It includes controlling the development of lymphoid organs,maintaining intact lymphoid structure,inducing immune response against pathogens,mediating the regeneration of organs and tissues,and participating in the evolution and development of tumors.The non-classical/classical nuclear transcription factor-kappaB(NF-κB)pathway through LTBR signaling induces the secretion of chemokines and adhesion molecules to promote cell proliferation and differentiation.LTBR signaling not only plays a role in autoimmune diseases,but also has different anti-cancer and pro-cancer functions through different models.In this paper,we will also focus on the regeneration mechanism of LTBR signal after organ development and related tissue damage,so as to open up a new perspective for regenerative medicine.

关 键 词：淋巴毒素-β受体 信号通路 组织再生 器官发育 

分 类 号：R392.1[医药卫生—免疫学]