丁苯酞联合血管内支架置入术治疗前循环大血管狭窄性脑卒中的疗效分析  

EFFECT ANALYSIS OF BUTYLPHTHALIDE COMBINED WITH ENDOVASCULAR STENT IMPLANTATION IN TREATMENT OF ANTERIOR CIRCULATION LARGE VESSEL STENOSIS STROKE

作　　者：刘泽民[1] 张强 穆珊珊[1] 柳桂红 李冠霞 LIU Zemin;ZHANG Qiang;MU shanshan;LIU Guihong;LI Guanxia(Tangshan People’s Hospital,Hospital,Tangshan 063000,China)

机构地区：[1]河北省唐山市人民医院神经内科,063000 [2]河北省唐山市人民医院重症医学二科

出　　处：《中国煤炭工业医学杂志》2022年第3期237-241,共5页Chinese Journal of Coal Industry Medicine

基　　金：2019年度河北省医学科学研究课题计划(编号:20191594)。

摘　　要：目的 探讨丁苯酞联合血管内支架置入术治疗前循环大血管狭窄性脑卒中的疗效。方法选择2018年1月—2021年6月唐山市人民医院神经内科收治的78例前循环大血管狭窄引起的缺血性脑卒中患者为观察对象,按照治疗方法不同分为对照组38例和观察组40例。对照组给予血管内支架置入术治疗及其他常规对症治疗。观察组在上述基础上联合应用丁苯酞注射液100 ml(丁苯酞25 mg与氯化钠0.9 g),每日二次静脉滴注,两次使用间隔不少于6小时,疗程14天;比较观察组和对照组治疗3个月后美国国立卫生研究院卒中量表(NIHSS)评分、巴塞尔指数(Barthel)评分、改良Rankin(mRS)评分差别及术后并发症情况。结果 观察组和对照组治疗前NIHSS评分、Barhtel指数评分及mRS评分比较,差异均无统计学意义(P>0.05);观察组NIHSS评分、mRS评分在治疗后明显低于对照组,而Barhtel指数评分在治疗后则明显高于对照组,差异均具有统计学意义(P<0.05)。经治疗后观察组基本治愈、显效、有效的总数为37例,其总有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗3个月后观察组出血颅内出血、血管再狭窄、再次梗塞及死亡的并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论 丁苯酞联合血管内支架置入术治疗前循环大血管狭窄性脑卒中可提高临床治疗效果,改善血管狭窄引起的神经功能障碍,明显降低术后并发症。Objective To investigate the efficacy of butylphthalide combined with endovascular stent implantation in the treatment of anterior circulation large vessel stenosis stroke.Methods A total of seventy-eight patients with ischemic stroke caused by anterior circulation great vessel stenosis admitted to The Department of Neurology,Tangshan People’s Hospital from January 2018 to June 2021 were selected as the observation subjects,and according to the treatment method group(n=38) and observation group(n=40).The control group received endovascular stent implantation and other conventional symptomatic treatment.The observation group was additionally combined with 100 ml butylphthalide injection(25 mg butylphthalide and 0.9 g sodium chloride),intravenous infusion twice daily with an interval of no less than 6 hours.The course of treatment was 14 days.The difference of NIHSS score,Barthel index score,modified Rankin(mRS) score and postoperative complications were compared between the observation group and the control group 3 months after treatment.Results There were no significant differences in NIHSS score,Barhtel index score and mRS score between the observation group and the control group before treatment(P>0.05).NIHSS score and mRS score in the observation group were significantly lower than those in the control group after treatment,while Barhtel index score was significantly higher than that in the control group after treatment,with statistical significance(P<0.05).After treatment,37 cases in the observation group were basically cured,significantly effective and effective after treatment,and the total effective rate was significantly higher than that in the control group,with statistical significance(P<0.05).After 3 months of treatment,the complication rate of intracranial hemorrhage,vascular restenosis,rebunching and death in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Butylphthalide combined with endovascular stent implantation

关 键 词：丁苯酞 血管内支架置入术 前循环大血管狭窄性脑卒中 

分 类 号：R541[医药卫生—心血管疾病]