中药治疗阿尔茨海默病分子作用机制的研究进展  

Research progress on molecular mechanism of traditional Chinese medicine in treatment of Alzheimer’s disease

作　　者：张晨曦 董承瑜 胡鑫 郑慧慧 郎尉雅[1] ZHANG Chen-xi;DONG Cheng-yu;HU Xin;ZHENG Hui-hui;LANG Wei-ya(Qiqihar Medical University,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔医学院,黑龙江齐齐哈尔161006

出　　处：《中草药》2022年第13期4132-4145,共14页Chinese Traditional and Herbal Drugs

基　　金：黑龙江省省属本科高校基本科研业务费项目(2021-KYYWF-0379);黑龙江省大学生创新创业训练计划项目(202111230017);齐齐哈尔市科技计划联合引导项目(LHYD-2021022)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是一种常见的进行性神经系统退行性疾病,起病隐匿,发病机制复杂,发病人数逐年上升,严重危害我国老年人的身心健康,因此疾病的早期预防与治疗至关重要。目前临床治疗AD药物尚不能有效阻止和显著延缓病程进展,近年中药防治AD作用逐步得到验证,已成为科学研究的热点问题。主要阐述了AD的发病机制,从错误蛋白的沉积及级联反应、神经炎症微环境、线粒体功能障碍、神经递质、铁死亡等层面总结了近年中药抗AD的分子机制等,有助于临床治疗策略的优化,为中药的开发及应用提供新的思路。Alzheimer’s disease(AD)is a common progressive degenerative disease of nervous system.Its attack is very hidden and pathogenesis is complicated.The number of cases is increasing year by year,seriously endangering the physical and mental health of the elderly in China.Therefore,the early prevention and treatment of disease is very important.At present,the clinical treatment of AD drugs cannot effectively prevent and significantly delay the progression of the disease.In recent years,the effect of traditional Chinese medicine on prevention and treatment of AD has been gradually verified and has become a hot issue in scientific research.Pathogenesis of AD and molecular mechanism of traditional Chinese medicine in treatment of AD from the deposition and cascade reaction of wrong proteins,neuroinflammatory microenvironment,mitochondrial dysfunction,neurotransmitters,ferroptosis were reviewed in this paper,in order to optimize clinical treatment strategy and provide certain ideas for development or application of traditional Chinese medicine.

关 键 词：阿尔茨海默病 发病机制 分子机制 神经炎症 神经递质 铁死亡 

分 类 号：R282.710.5[医药卫生—中药学]