木通属植物提取物抗肿瘤作用的研究进展  

Research advances on anti-tumor effects of plants of Akebia extracts

作　　者：曹琳娜 彭佩克 潘志强[1] CAO Lin-na;PENG Pei-ke;PAN Zhi-qiang(School of Basic Medical Sciences,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学基础医学院,上海201203

出　　处：《中草药》2022年第13期4187-4197,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金青年基金项目(82004000);上海市科委科研基金项目(19140905000)。

摘　　要：木通属AkebiaDecne.目前发现5种,其植物在中医药治疗上应用广泛,药用品种主要是木通(五叶木通)Akebia quinate、三叶木通A.trifoliata和白木通A.trifoliate subsp.australis;主要药用部位为其藤茎和果实,具有利尿通淋和疏肝理气等功效。近年来木通属植物也常用于中医药的肿瘤防治,许多研究表明其提取物对胃癌、肝癌等肿瘤细胞的增殖产生抑制作用,而来自木通属植物不同部位提取物的抗癌作用也不尽相同,其抗肿瘤机制包括诱导凋亡、抑制侵袭与转移、阻滞细胞周期、抑制肿瘤细胞血管生成等。对木通属植物的藤茎、果实、种子提取物和其天然产物的抗肿瘤作用研究进行归纳综述,为木通属植物在中医药肿瘤防治方面的应用提供新思路。The plants of Akebia are widely used in traditional Chinese medicine treatment,and the stem and fruit of which are considered as main medicinal parts to execute the function of promoting diuresis,relieving stranguria,soothing the liver and regulating vital energy.Recent researches demonstrate that plants of Akebia.can be applied in the prevention and treatment of malignant tumors,and that the plant extracts can inhibit the proliferation of cancer cells,such as gastric cancer cells and hepatoma cells.However,different parts of Akebia have different pharmacological effects.It is of great significance to understand the anti-tumor effect of the extracts of Akebia,for further separating its active pharmacological ingredients and exploring the anti-tumor mechanism.This article summarizes the researches on the anti-tumor effects of the extracts of stem,fruit,seed and natural product from the plants of Akebia,to provide new ideas for the application of plants of Akebia.in traditional Chinese medicine treatment.

关 键 词：木通属 木通 三叶木通 白木通 预知子 提取物 抗肿瘤 

分 类 号：R28[医药卫生—中药学]