木香的化学成分、药理作用、临床应用研究进展及质量标志物预测  

Research progress on chemical constituents,pharmacological effects and clinical applications of Aucklandiae Radix and prediction analysis on Q-Marker

作　　者：郑加梅 尚明越 王嘉乐 代国娜 宋经元[2] 段宝忠 ZHENG Jia-mei;SHANG Ming-yue;WANG Jia-le;DAI Guo-na;SONG Jing-yuan;DUAN Bao-zhong(College of Pharmaceutical Science,Dali University,Dali 671000,China;Institute of Medicinal Plants Development,Chinese Academy of Medical Sciences,Beijing 100093,China)

机构地区：[1]大理大学药学院,云南大理671000 [2]中国医学科学院药用植物研究所,北京100093

出　　处：《中草药》2022年第13期4198-4213,共16页Chinese Traditional and Herbal Drugs

基　　金：云南省重大科技专项(202002AA100007);云南省院士专家工作站(202205AF150026,202105AF150053);云南省兴滇英才支持计划(YNWR-QNBJ-2020251)。

摘　　要：木香为我国传统大宗药材,是多种中成药的原料,《中国药典》2020版一部以木香烃内酯和去氢木香内酯作为指标成分,难以系统阐释木香“功效-成分-质量”的关系。近年来,国内外学者对木香各方面研究逐渐深入,许多新的化学成分与药理作用不断被发现。在对其化学成分和药理作用进行系统总结的基础上,根据质量标志物的核心理念,从植物亲缘、药效、药性、配伍、化学成分可测性等方面,对木香质量标志物进行预测分析,以期为木香质量评价体系的建立健全提供参考。As the traditional bulk medicinal material,Muxiang(Aucklandiae Radix)is the raw material of many kinds of Chinese patent medicines.It was difficult to systematically explain the relationship between"efficacy,composition and quality"of Aucklandiae Radix using costunolide and dehydrocostus lactone as index components in Chinese Pharmacopoeia 2020 edition.In recent years,with the in-depth investigation of Aucklandiae Radix,many new chemical components and pharmacodynamics have been found.According to the chemical component and pharmacological effect research,the quality markers of Aucklandiae Radix were predicted from the aspects of plant affinity,efficacy,drug property,compatibility and chemical composition measurability,etc.This review provides systematic and constructive information for the quality evaluation of Aucklandiae Radix.

关 键 词：木香 化学成分 抗肿瘤 抗炎 抗菌 临床应用 质量标志物 香烃内酯 去氢木香内酯 

分 类 号：R286.2[医药卫生—中药学]