抗肿瘤作用的海洋中药  

Marine traditional Chinese medicine with antitumor effects

作　　者：李泽宇 郝二伟[1,2] 李卉 王嘉玉 李心鑫 曹瑞 庄培钧 肖倩 韦柳溢[1,2] 杜正彩 侯小涛 邓家刚[1,2] LI Ze-yu;HAO Er-wei;LI Hui;WANG Jia-yu;LI Xin-xin;CAO-Rui;ZHUANG Pei-jun;XIAO Qian;WEI Liu-yi;DU Zheng-cai;HOU Xiao-tao;DENG Jia-gang(China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research,Guangxi University of ChineseMedicine,Nanning 530200,China;Institute of Marine Medicine,Guangxi University of Traditional Chinese Medicine,Nanning 530000,China;Wangjing Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100102,China;Beijing Longfu Hospital,Beijing 100010,China)

机构地区：[1]广西中医药大学中国-东盟传统医学研究国际合作联合实验室,广西南宁530200 [2]广西中医药大学海洋药物研究院,广西南宁530000 [3]中国中医科学院望京医院,北京100102 [4]北京市隆福医院,北京100010

出　　处：《中草药》2022年第14期4527-4544,共18页Chinese Traditional and Herbal Drugs

基　　金：中国-东盟传统药物研究国际合作联合实验室建设(二期)新中心建设项目(CICAR2017-Z1);广西科技基地和人才专项(桂科AD191101553);广西创新驱动重大专项(桂科AA181180492);广西创新驱动重大专项(桂科AA192540334)。

摘　　要：海洋中药应用历史悠久,是海洋生物资源和中医药研究中的重要组成部分。肿瘤一直以来都是人类面临的重大难题,化疗药物不良反应大、易耐药等问题日渐突出,现代研究已证实多种海洋中药具有显著的抗肿瘤作用,开发潜力较大,因此从该领域筛选合适的抗肿瘤药物意义重大。通过文献挖掘《海洋中药学》中记载的250种经典海洋中药,发现抗肿瘤作用已得到验证的有47种,清热解毒类、补虚类、化痰止咳平喘类、祛风湿类海洋中药占比较大,其药效物质主要为多肽、多糖类成分。综述具有抗肿瘤作用的海洋中药,为海洋中药更深层次的抗肿瘤研究提供一定的借鉴意义和思路方法。Marine traditional Chinese medicine(TCM)has a long history of application,and is an important part of marine biological resources and TCM research.Tumor has always been a major challenge for mankind.The problems of large adverse reactions and easy drug resistance to chemotherapeutic drugs are becoming increasingly prominent.Modern research has confirmed that a variety of marine TCMs have significant antitumor effects and great development potential.Therefore,it is significant to screen appropriate antitumor drugs from this field.In this paper,through the literature mining of 250 classical marine TCM recorded in“Marine Traditional Chinese Medicine”,it is found that 47 kinds of antitumor effects have been verified,the proportion of marine TCMs such as heat clearing and toxin removing classes,tonify deficiency classes,resolving phlegm and relieving cough and asthma classes,and dispel rheumatism classes are relatively large,and their pharmacodynamic substances are mainly peptides and polysaccharides.The review of marine TCM with the anti-tumor effects will provide some reference significance and ideas and methods for the deeper antitumor research of marine TCM.

关 键 词：海洋中药 抗肿瘤 多肽 多糖 清热解毒类 补虚类 化痰止咳平喘类 祛风湿类 

分 类 号：R282.710.5[医药卫生—中药学]