静脉用丙种球蛋白联合地塞米松治疗儿童免疫性血小板减少症的效果  

Effect of intravenous gamma globulin combined with dexamethasone in the treatment of immunologic thrombocytopenic purpura in children

作　　者：杨宪辉 YANG Xian-hui(Department of Pediatrics,Chaoyang Central Hospital,Chaoyang 122000,China)

机构地区：[1]朝阳市中心医院儿科,122000

出　　处：《中国现代药物应用》2022年第13期34-37,共4页Chinese Journal of Modern Drug Application

摘　　要：目的研究静脉用丙种球蛋白联合地塞米松治疗儿童免疫性血小板减少症(ITP)的效果。方法62例ITP患儿作为研究对象,以随机抽签法分为对照组和观察组,各31例。对照组采用地塞米松治疗,观察组在对照组基础上增加静脉用丙种球蛋白治疗。比较两组患儿血小板指标改善情况,治疗前后血常规指标水平,治疗效果。结果观察组患儿的血小板上升时间(1.2±0.8)d、血小板复常时间(3.4±1.2)d、止血时间(2.5±1.1)d均早于对照组的(2.3±1.2)、(4.8±1.5)、(3.8±1.2)d,血小板峰值(147.5±45.8)×10^(9)/L高于对照组的(120.1±40.3)×10^(9)/L,差异具有统计学意义(P<0.05)。治疗前,两组患儿的血小板计数以及白细胞计数比较差异均无统计学意义(P>0.05);治疗后,观察组患儿的血小板计数(123.6±11.6)×10^(9)/L显著高于对照组的(70.6±7.8)×10^(9)/L,白细胞计数(3.8±1.6)×10^(9)/L显著低于对照组的(5.3±1.9)×10^(9)/L,差异具有统计学意义(P<0.05)。观察组患儿的治疗总有效率为93.5%,明显高于对照组的74.2%,差异具有统计学意义(P<0.05)。结论ITP患儿采用静脉用丙种球蛋白及地塞米松联合治疗,可发挥各自的药理作用,提升患儿身体机能及免疫力,保证治疗效果。Objective To study the effect of intravenous gamma globulin combined with dexamethasone in the treatment of immunologic thrombocytopenic purpura(ITP)in children.Methods A total of 62 children with ITP were selected as the research subjects and randomly divided into control group and observation group,with 31 cases in each group.The control group was treated with dexamethasone,and the observation group was additionally treated with intravenous gamma globulin on the basis of the control group.The improvement of platelet indicators,blood routine indexes before and after treatment,and the therapeutic effect were compared between the two groups.Results The platelet rise time(1.2±0.8)d,platelet normalization time(3.4±1.2)d,and hemostasis time(2.5±1.1)d in the observation group were earlier than(2.3±1.2),(4.8±1.5),and(3.8±1.2)d in the control group,and the peak platelet(147.5±45.8)×10^(9)/L was higher than(120.1±40.3)×10^(9)/L in the control group.All the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in platelet count and white blood cell count between the two groups(P>0.05).After treatment,the platelet count(123.6±11.6)×10^(9)/L in the observation group was significantly higher than(70.6±7.8)×10^(9)/L in the control group,and the white blood cell count(3.8±1.6)×10^(9)/L was significantly lower than(5.3±1.9)×10^(9)/L in the control group.All the differences were statistically significant(P<0.05).The total effective rate in the observation group was 93.5%,which was significantly higher than 74.2%in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of intravenous gamma globulin and dexamethasone in children with ITP can give full play to their respective pharmacological effects,enhance the physical function and immunity of the child,and ensure the therapeutic effect.

关 键 词：免疫性血小板减少症 地塞米松 丙种球蛋白 静脉用药 血小板指标 

分 类 号：R725.5[医药卫生—儿科]