浓缩生长因子作为生物敷料在稳定期节段型白癜风自体表皮移植术中的应用  

Clinical effect of concentrated growth factors coating in the treatment of stable segmental vitiligo with autologous epidermal transplantation

作　　者：范飞翔 黄珍 侯占英 刘坡 FAN Feixiang;HUANG Zhen;HOU Zhanying;LIU Po(Shenzhen Longhua District Central Hospital,Shenzhen 518110,China)

机构地区：[1]深圳市龙华区中心医院,广东深圳518110

出　　处：《皮肤性病诊疗学杂志》2022年第4期317-321,共5页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：深圳市龙华区医疗卫生机构区级科研项目(20200165)。

摘　　要：目的 观察浓缩生长因子在稳定期节段型白癜风自体表皮移植中应用的有效性及安全性。方法 纳入65例面部稳定期节段型白癜风患者,随机分为治疗组33例和对照组32例。所有患者均行自体表皮移植,治疗组移植区覆盖自体表皮后,加盖自体浓缩生长因子凝胶膜,然后凡士林纱布覆盖,无菌纱布加压包扎。对照组仅覆盖凡士林纱布。术后两周后,两组患者均行308 nm准分子光照射及外用0.1%他克莫司乳膏。规律随访至术后6个月。结果 治疗后6个月,治疗组、对照组有效率分别为93.94%和75.00%,差异有统计学意义(χ^(2)=12.44,P=0.040);色素沉着发生率分别为9.09%和31.25%,差异有统计学意义(χ^(2)=4.99,P=0.026);光晕现象发生率分别为15.15%和37.50%,差异有统计学意义(χ^(2)=4.20,P=0.040)。治疗组感染发生率为3.03%,对照组感染发生率为6.06%,差异无统计学意义(χ^(2)<0.01,P=0.978)。结论 浓缩生长因子作为生物敷料在节段型白癜风自体表皮移植中应用安全有效,值得临床推广。Objective To evaluate the effect and adverse effects of concentrated growth factors coating in the treatment of stable segmental vitiligo with autologous epidermal transplantation. Methods Sixty-five patients with facial segmental vitiligo were randomized into the treatment group(n=33) and the control group(n=32). All patients underwent autologous epidermal transplantation. In the treatment group, the grafted area was covered with autologous epidermis, then covered with concentrated growth factors coating. Finally, vaseline gauze was used to cover the grafted area, and the gauze was pressure bandaged. In the control group the grafted area was only dressed with Vaseline gauze, and the gauze was pressure bandaged. All patients received 308 nm excimer light and topical 0.1% tacrolimus ointment beginning at 2 weeks after surgery. Postoperatively, patients were scheduled for routine follow-up to six months. Results After 6 months treatment, the effective rates for patients in the treatment group and in the control group were 93.94% and 75.0%, respectively, with significant difference between the groups( χ^(2)=12.44,P=0.040). The incidence of pigmentation for patients in the treatment group and in the control group was 9.09% and 31.25%, respectively, with significant difference between the groups( χ^(2)=4.99,P=0.026). The incidence of halo phenomenon for patients in the treatment group and in the control group was 15.15% and 37.50%, respectively, with significant difference between the groups( χ^(2)=4.20,P=0.040). The incidence of infection for patients in the treatment group and in the control group was 3.03% and 6.06%, respectively, with no significant difference between two groups( χ^(2)<0.01,P=0.978). Conclusion The use of concentrated growth factors coating for autologous epidermal transplantation in stable segmental vitiligo patients is feasible, safe, and effective.

关 键 词：浓缩生长因子 节段型白癜风 自体表皮移植 生物敷料 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]