早产儿出生时维生素D缺乏的临床研究  

Clinical study of vitamin D deficiency in premature infants at birth

作　　者：霍洁 王磊[1] 管峥 赵娟娟 吴新萍 HUO Jie;WANG Lei;GUAN Zheng(Department of Neonatology,Affiliated Hospital of Medical College of Yangzhou University Yangzhou Maternity and Child Health Care Hospital,Yangzhou 225002,China)

机构地区：[1]扬州大学医学院附属医院扬州市妇幼保健院新生儿科,江苏扬州225002

出　　处：《吉林医学》2022年第8期2061-2065,共5页Jilin Medical Journal

基　　金：扬州市科技局资助项目[项目编号:YZ2018083]。

摘　　要：目的:通过检测早产儿生后24小时内血清25-羟基维生素D[25(OH)D]水平,了解早产儿维生素D缺乏的发生情况,为下一步早产儿维生素D的补充提供优化方案,预防维生素D缺乏相关疾病的发生。方法:选取早产儿506例,入院后24 h内采用酶联免疫检测法检测血清25(OH)D值,根据结果分为维生素D缺乏组和非缺乏组,通过病例系统回顾性收集母亲和早产儿的相关临床数据进行分析。结果:最终纳入早产儿487例,其中维生素D缺乏早产儿283例,维生素D缺乏的发生率为58.1%。平均胎龄为35周,男143例(50.5%),其平均25(OH)D水平为(40.78±6.02)nmol/L。春夏出生的早产儿血清25(OH)D为(41.44±5.14)nmol/L,秋冬出生的早产儿血清25(OH)D为(40.12±6.39)nmol/L,两组血清25-(OH)D浓度差异有统计学意义(P<0.05)。在极早产儿组中,男和女25(OH)D水平两组有差异;不同出生体重的维生素D缺乏发生率略有差异。结论:早产儿维生素D缺乏的发生率仍不低(58.1%),需进一步研究相关影响因素,优化早产儿补充维生素D的管理策略。Objective To understand the incidence of vitamin D deficiency in preterm infants by detect the serum 25(OH) D level in 24 hours after the birth,and to provide an optimized scheme for the next step of vitamin D supplementation in preterm infants,so as to prevent the incidence of vitamin D deficiency related diseases.Method 506 premature infants were enrolled 487 premature infants were included in the study.Within 24 hours after admission,enzyme-linked immunosorbent assay was used to detect serum 25(OH) D value.According to the results,they were divided into vitamin D deficiency group and non deficiency group.The relevant clinical data of mothers and premature infants were collected and analyzed by case system retrospective analysis.Results 487 preterm infants were included,283 of them were vitamin D deficient,the incidence of vitamin D deficiency was 58.1%;the average gestational age was 35 weeks,143 of them were male(50.5%),the average 25(OH) D level was(40.78±6.02) nmol/L;the serum 25(OH) D of preterm infants born in spring and summer was(41.44±5.14) nmol/L,the serum 25(OH)D of preterm infants born in autumn and winter was(40.12±6.39) nmol/L,there was a significant difference between the two groups in serum 25-(OH) D concentration(P<0.05);in the very premature group,there was a difference between the two groups in the level of 25(OH) D in men and women;the incidence of vitamin D deficiency in different birth weight was slightly different.Conclusion The incidence of vitamin D deficiency in preterm infants is still not low(58.1%).It is necessary to further study the related factors and optimize the management strategy of vitamin D supplementation for premature infants.

关 键 词：早产儿 25-羟基维生素D 维生素D缺乏 

分 类 号：R722.6[医药卫生—儿科]