前列腺素F_(2α)及其类似物对哺乳动物生殖影响的研究进展  

Research Progress on the Effects of Prostaglandin F_(2α)and Its Analogues on the Reproductive Performance of Mammal

作　　者：朱雪丹 潘学情 马君艳 周乐乐 张守全 ZHU Xuedan;PAN Xueqing;MA Junyan;ZHOU Lele;ZHANG Shouquan(College of Animal Science,South China Agricultural University,National Engineering Research Center for Breeding Swine Industry,Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding,Guangzhou 510642,China)

机构地区：[1]华南农业大学动物科学学院,国家生猪种业工程技术研究中心,广东省农业动物基因组学与分子育种重点实验室,广州510642

出　　处：《中国畜牧兽医》2022年第8期3072-3082,共11页China Animal Husbandry & Veterinary Medicine

基　　金：国家重点研发计划项目(2018YFD0501001、2017YFD0501902);广东省现代农业产业技术体系生猪创新团队(2020KJ126)。

摘　　要：前列腺素F_(2α)(prostaglandin F_(2α),PGF_(2α))是一种黄体溶解因子,广泛用于母猪的同期发情和分娩启动。近年来还陆续发现PGF_(2α)的新功能,内源性PGF_(2α)可作为哺乳动物的妊娠识别信号,与胎体和子宫内膜PGF_(2α)受体(PGF_(2α)receptor,FP)结合,启动下游信号通路,对早期胚胎发育、着床、妊娠维持发挥重要作用,缺乏或合成不足会导致妊娠中断或流产。鉴于PGF_(2α)对母畜繁殖活动的促进作用,兽药中心研发了多种PGF_(2α)药物,如氯前列醇钠、地诺前列腺素F_(2α)等,被广泛用来启动分娩和促进发情。根据氯前列醇钠的旋光性,可分为D-型和L-型两种对映体,其中D-型结构是氯前列醇钠的主要活性成分。外源性PGF_(2α)药物不仅可以诱导母猪同期发情与同步分娩、促进产后健康,提高断奶母猪发情率,还可以改善母猪泌乳力与初乳质量,提高仔猪活力等生产性状。作者综述了近几年国内外PGF_(2α)的研究进展,包括PGF_(2α)对周期黄体的双重作用,PGF_(2α)对早期胚胎的发育、着床、分娩的影响,PGF_(2α)对母猪泌乳力及仔猪活力等方面的重要作用等,同时也综述了几种PGF_(2α)及其类似物对母畜繁殖性能等方面的影响,旨在为PGF_(2α)及其类似物的合理运用提供依据。Prostaglandin F_(2α)(PGF_(2α)) is a luteinolytic factor,which is widely used in estrus synchronization and induced parturition in sows.In recent years,new functions of PGF_(2α) have been found one after another.As a pregnancy recognition signal of mammals,endogenous PGF_(2α) can bind to PGF_(2α) receptor(FP)in the fetus and endometrium,initiate downstream signal pathways,and play an important role in early embryonic development,implantation and pregnancy maintenance.Lack or insufficient synthesis will lead to pregnancy interruption or abortion.In view of the promoting effect of PGF_(2α) on the reproduction activities of female animals,the veterinary drug center has developed a variety of PGF_(2α) drugs,such as sodium chloroprostol,dinoprostaglandin F_(2α) and so on,which are widely used to start delivery and promote estrus.According to the optical activity of sodium chloroprostol,it can be divided into D-type and L-type enantiomers,in which D-type structure is the main active component of sodium chloroprostol.Exogenous PGF_(2α) drugs can not only induce simultaneous estrus and synchronous delivery of sows,promote postpartum health and increase the estrus rate of weaned sows,but also improve sow lactation ability and colostrum quality,improve piglet vitality and other production traits.This paper reviews the research progress of new functions of PGF_(2α) at home and abroad in recent years,including the dual effects of PGF_(2α) on periodic corpus luteum,the important effects of PGF_(2α) on early embryo development,implantation and late pregnancy delivery,as well as the important effects of PGF_(2α) on sow lactation and piglet vitality.It also summarizes the effects of several PGF_(2α) and its analogues on reproductive performance of female animals.The purpose of this study is to provide theoretical basis for the rational use of PGF_(2α) and its analogues.

关 键 词：前列腺素F_(2α) 着床 分娩 早期胚胎发育 黄体溶解 

分 类 号：S826.8[农业科学—畜牧学]