外泌体在血栓中的研究进展  

Research progress of exosomes in thrombosis

作　　者：罗吉 周如丹[1] 赵学凌[1] LUO Ji;ZHOU Ru-Dan;ZHAO Xue-Ling(Department of Orthopaedics,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院骨科,昆明650032

出　　处：《生命科学》2022年第6期711-718,共8页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81760030);云南省科技厅昆明医科大学应用基础研究联合专项项目(202001A7070001-185);云南省临床医学研究中心子课题(202102AA310088)。

摘　　要：外泌体是一种由细胞内吞再分泌的纳米级囊泡结构物质,包含microRNA、siRNA、蛋白质、脂质等成分。在不同的应激刺激条件下,细胞通过分泌不同的外泌体参与机体组织细胞的生理、病理等过程。血栓是指心脏或血管内异常形成的血凝块。在血栓形成过程中,多种来源的外泌体调节该过程。外泌体作为一种可能预测血栓的血液诊断标记物,有着重要的研究意义。该文综述了在血栓形成中外泌体的研究现状,总结了外泌体调控血栓的可能机制,以期为今后血栓的诊断治疗和研究提供依据。Exosomes are a kind of nanometer-sized vesicles,which are re-secreted after cells endocytosis.They contain microRNA,siRNA,protein,lipid and other components.In different stress-stimulated conditions,some cells are involved in physiological and pathological processes by secreting different exosomes.Thrombus is an abnormal blood clot formed in the heart or vessels.In the development of thrombosis,exosomes secreted by cells could regulate this pathological process,so exosomes may be used as the diagnostic markers to predict thrombosis,which is worthy of research.The research progress of exosomes in thrombosis and the possible mechanism of exosomes in regulating thrombosis are summarized here,to provide the basis for the diagnosis,treatment and research of thrombosis in the future.

关 键 词：外泌体 血栓 MICRORNAS 中性粒细胞胞外陷阱 血小板 

分 类 号：R619.2[医药卫生—外科学]