盐酸甲氧氯普胺注射液致嗜铬细胞瘤患者高血压危象  

Metoclopramide hydrochloride injection-induced hypertensive crisis in a patient with pheochromocytoma

作　　者：陈晓琳 李海僖 杨洁[2] 杨海 Chen Xiaolin;Li Haixi;Yang Jie;Yang Hai(Department of Pharmacy,Qingdao Central Hospital,Shandong Province,Qingdao 266042,China;Department of Pharmacy,Shandong Provincial Hospital,Jinan 250021,China)

机构地区：[1]青岛市中心医院药学部,青岛266042 [2]山东省立医院药学部,济南250021

出　　处：《药物不良反应杂志》2022年第7期371-373,共3页Adverse Drug Reactions Journal

基　　金：青岛市中医药科研计划项目(2020-zyy027);青岛市医药科研计划(2019-WJZD063)。

摘　　要：1例64岁副神经节瘤女性患者,使用盐酸甲氧氯普胺注射液10 mg肌内注射预防化疗引起的呕吐,5 min后出现心悸、出汗、头痛、四肢无力等不适症状,血压升高至214/101 mmHg(1 mmHg=0.133 kPa),诊断为高血压危象,给予乌拉地尔25 mg静脉注射,并持续监测患者血压,约12 h后患者症状好转,血压逐渐恢复正常。说明书提示嗜铬细胞瘤和副神经节瘤患者禁用甲氧氯普胺。本例患者因使用该药发生高血压危象,延长了住院时间,属于F级用药错误。A 64-year-old female patient with paraganglioma received intramuscular injection of metoclopramide hydrochloride injection 10 mg to prevent chemotherapy-induced vomiting.Five minutes later,he developed palpitation,sweating,headache,limb weakness,and other discomfort symptoms,and the blood pressure increased to 214/101 mmHg.Hypertensive crisis was diagnosed.Urapidil 25 mg was given intravenously,and the blood pressure in the patient was continuously monitored.About 12 hours later,the patient′s symptoms were improved and the blood pressure gradually returned to normal.It is suggested in the label that metoclopramide should not be used in patients with pheochromocytoma and paraganglioma.The patient suffered from hypertension crisis due to the use of the drug,and the hospital stay was prolonged,so it was grade F medication error.

关 键 词：甲氧氯普胺 嗜铬细胞瘤 副神经节瘤 肾上腺外 用药错误 高血压危象 

分 类 号：R969.3[医药卫生—药理学]