卡格列净致急性肾损伤  

Acute kidney injury induced by canagliflozin

作　　者：张红梅[1] 郭秋实[1] 田旭[1] 孙丽蕊[1] Zhang Hongmei;Guo Qiushi;Tian Xu;Sun Lirui(Department of Pharmacy,the First Hospital of Jilin University---the Eastern Division,Changchun 130031,China)

机构地区：[1]吉林大学第一医院二部药学部,长春130031

出　　处：《药物不良反应杂志》2022年第7期376-377,共2页Adverse Drug Reactions Journal

摘　　要：1例45岁男性患者因2型糖尿病血糖控制不佳应用卡格列净100 mg口服、1次/d。用药第4天出现轻微腹胀、乏力;第5天,患者恶心、浑身乏力,尿液呈深棕色,实验室检查:血清肌酐(Scr)136μmol/L,血尿素氮(BUN)9.7 mmol/L,尿蛋白(+),尿潜血(++)。考虑为卡格列净引起的急性肾损伤,停用该药并给予阿卡波糖50 mg餐前口服、3次/d,海昆肾喜胶囊2粒口服、3次/d,金水宝胶囊3粒口服、3次/d。停用卡格列净2 d后患者恶心、乏力症状消失,尿液颜色正常。停药5 d后患者实验室检查:空腹血糖5.6 mmol/L,Scr 112μmol/L,BUN 8.5 mmol/L,尿蛋白(-),尿潜血(-)。19 d后复查肾功能指标均在正常值范围,患者未再出现不适症状。A 45-year-old male patient was treated with canagliflozin 100 mg once daily orally for type 2 diabetes mellitus due to poor blood sugar control.On the 4th day of medication,the patient developed slight abdominal distension and fatigue;on the 5th day,the patient felt nausea and general fatigue,and the color of urine became dark brown.The laboratory tests showed serum creatinine(Scr)136μmol/L,blood urea nitrogen(BUN)9.7 mmol/L,urine protein(+),and urinary occult blood(++).Acute kidney injury induced by canagliflozin was considered.Canagliflozin was stopped,and acarbose 50 mg(before meal),2 Haikun Shenxi capsules(海昆肾喜胶囊),and 3 Jinshuibao capsules(金水宝胶囊)orally thrice daily were given.After 2 days of drug withdrawal,the symptoms of nausea and fatigue disappeared,and the color of urine was normal.After 5 days of drug withdrawal,laboratory tests showed fasting blood glucose 5.6 mmol/L,Scr 112μmol/L,BUN 8.5 mmol/L,urine protein(-),and urine occult blood(-).After 19 days of drug withdrawal,the patient′s renal function indexes were all within the normal range,and no discomfort symptoms recurred.

关 键 词：卡格列净 钠-葡萄糖转运蛋白2抑制剂 急性肾损伤 

分 类 号：R969.3[医药卫生—药理学]