植物3-羟基-3-甲基戊二酰辅酶A还原酶(HMGR)研究进展  

Research progress of 3-hydroxy-3-methylglutaryl-CoA reductase in plants

作　　者：郑婷[1] 魏灵珠[1] 程建徽[1] 向江 吴江[1] ZHENG Ting;WEI Lingzhu;CHENG Jianhui;XIANG Jiang;WU Jiang(Institute of Horticulture,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021,China)

机构地区：[1]浙江省农业科学院园艺研究所,杭州310021

出　　处：《植物生理学报》2022年第6期1037-1044,共8页Plant Physiology Journal

基　　金：现代农业产业技术体系建设专项(CARS-29-13);国家自然科学基金(31801822)。

摘　　要：3-羟基-3-甲基戊二酰辅酶A还原酶(3-hydroxy-3-methylglutaryl-CoA reductase,HMGR)是甲羟戊酸途径(mevalonate pathway,MVA)的第一个限速酶,在植物细胞质萜类化合物合成过程中起着关键作用,不仅对植物的生长发育至关重要,而且对植物适应苛刻的环境条件也很重要。本文就植物HMGR的结构特征、生物学功能及其调控机制的相关研究进展进行综述,旨在为园艺植物的遗传改良及新品种的培育提供分子基础和理论依据。3-Hydroxy-3-methylglutaryl-CoA reductase(HMGR) is a key enzyme in the mevalonate(MVA)pathway,which regulates the metabolism of terpenoids in the cytoplasm and determines the type and content of downstream terpenoid metabolites,critical not only for normal plant development,but also for the adaptation to demanding environmental conditions.Here,the progress in the characteristics of structure,biological functions,and regulation mechanism of HMGR are reviewed.All these will provide molecular and theoretical basis for the genetic improvement of horticultural plants and the cultivation of new varieties.

关 键 词：植物 萜类化合物 3-羟基-3-甲基戊二酰辅酶A还原酶(HMGR) 结构特征 生物学功能 

分 类 号：Q946.5[生物学—植物学]