补肾化痰活血法对视神经脊髓炎谱系疾病缓解期患者疼痛的疗效观察  

Therapeutic effect observation of tonifying kidney-resolving phlegm-activating blood treatment on patients with neuromyelitis optica spectrum disorders during remission complaining pain

作　　者：仝延萍 杨涛[1,2] 王静文 赵天佑 康越之 樊永平 TONG Yan-ping;YANG Tao;WANG Jing-wen;ZHAO Tian-you;KANG Yue-zhi;FAN Yong-ping(Department of Traditional Chinese Medicine,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Beijing Integrative Medicine on Encephalopathy Institution,Beijing 100070,China;Beijing Miyun District Hospital of Traditional Chinese Medicine,Beijing 101599,China)

机构地区：[1]首都医科大学附属北京天坛医院中医科,北京100070 [2]北京市中西医结合脑病研究所,北京100070 [3]北京市密云区中医院,北京101599

出　　处：《中华中医药杂志》2022年第7期4186-4189,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：首都卫生发展科研专项(No.首发2020-2-2043);北京市属医院科研培育计划项目(No.PZ2021006);国家自然科学基金(No.82074350);首都医科大学科研培育基金(No.PYZ20094);首都医科大学附属北京天坛医院科研培育基金(No.YZR-2021-12)。

摘　　要：目的:评价补肾化痰活血法治疗视神经脊髓炎谱系疾病(NMOSD)缓解期患者疼痛的临床疗效。方法:采用前瞻性自身前后对照的研究方法,纳入2016年12月至2017年12月就诊的缓解期NMOSD伴疼痛患者23例,给予补肾化痰活血法中药治疗,疗程6个月。应用视觉模拟评分法(VAS)评估患者疼痛程度,应用汉密尔顿抑郁量表和焦虑量表(HRSD和HAMA)评估患者是否存在抑郁与焦虑,应用多发性硬化影响量表(MSIS-29)评估疾病对患者生活质量的影响程度,应用扩展残疾状态量表(EDSS)评估患者神经功能损伤情况。计算治疗前后年复发率(ARR)。结果:治疗后患者VAS评分、MSIS-29评分、HAMA评分和EDSS评分均较治疗前显著降低(P<0.01,P<0.05),ARR显著下降(P<0.01)。结论:补肾化痰活血法能有效改善NMOSD缓解期患者的疼痛症状,提高患者生活质量。Objective:To evaluate the therapeutic effect of tonifying kidney-resolving phlegm-activating blood treatment on patients with neuromyelitis optica spectrum disorders(NMOSD)complaining pain.Methods:By using a prospective self-control research method,23 patients with NMOSD during remission complaining pain from December 2016 to December 2017 were treated with traditional Chinese medicine of tonifying kidney-resolving phlegm-activating blood method for 6 months.Visual analogue scale(VAS)was used to evaluate the degree of pain,Hamilton rating scale for depression(HRSD)and Hamilton anxiety scale(HAMA)were used to evaluate the existence of depression and anxiety,multiple sclerosis impact scale(MSIS-29)was used to evaluate the impact of disease on the quality of life,and extended disability status scale(EDSS)was used to evaluate the neurological impairment of patients.The annual recurrence rate(ARR)before and after treatment was calculated.Results:After treatment,VAS score,MSIS-29 score,HAMA score and EDSS score were significantly lower than those before treatment(P<0.01,P<0.05),and ARR was significantly lower(P<0.01).Conclusion:The method of tonifying kidney-resolving phlegm-activating blood can effectively improve the pain symptoms and quality of life of patients with NMOSD during remission.

关 键 词：视神经脊髓炎谱系疾病 缓解期 疼痛 补肾化痰活血法 二黄方 补肾益髓胶囊 量表 

分 类 号：R277.7[医药卫生—中医学]