氧合器内部流场特性分析与溶血评估  

Analysis of Flow Field Characteristics and Hemolysis Evaluation in Oxygenator

作　　者：刘德平[1] 郑凯[1] 李冬梅 LIU Deping;ZHENG Kai;LI Dongmei(School of Mechanical and Power Engineering,Zhengzhou University,Zhengzhou 450001,China;Guangdong Shunde Innovation Design Institute,Foshan 528300,China)

机构地区：[1]郑州大学机械与动力工程学院,河南郑州450001 [2]广东顺德工业设计研究院,广东佛山528300

出　　处：《郑州大学学报（工学版）》2022年第5期39-45,共7页Journal of Zhengzhou University（Engineering Science）

基　　金：河南省重大科技专项(171100210300-01)。

摘　　要：氧合器内部流体运动特性对其性能有着重要影响,实际中却难以通过实验直接观察其内部血液流动特性。为了解氧合器内部流体运动特性以预测其性能,针对一款典型氧合器,采用压降实验与CFD数值模拟相结合的方法,详细分析了该氧合器内部整体血液速度、压力和壁面剪切应力等特性分布规律,利用溶血预估模型评估了氧合器溶血性能。研究结果表明:在低流量范围内,各向同性多孔介质模型能够很好地模拟血液在氧合器纤维束内的流动,数值模拟计算值与实验值相差较小,但随着流量增加,两者偏差逐渐增大;氧合器内部速度呈梯度分布形式,内部纤维束域的压力呈同心均匀分布并且压力值与流量大小呈正相关,纤维束域是压力损失的主要区域;血液损伤高发位置分布于血液的进、出口流域,在实验流量范围内,标准溶血指数NIH最大值为0.049 2 g/100 L,符合氧合器的一般设计要求。研究结果有利于开发者了解氧合器内部流体运动特性对其性能的影响,为氧合器后续的性能改善提供参考。Fluid motion in oxygenator has an important influence on its performance,but it is difficult to observe its internal hemodynamics directly.In order to understand the fluid movement characteristics in an oxygenator and predict its performance,this study analyzed the distribution of blood velocity,pressure and wall shear stress in a typical oxygenator through pressure drop experiment and CFD numerical simulation.The hemolysis performance of the oxygenator was evaluated by the hemolysis prediction model.The research results indicated that in the low flow range,the simulated value of the isotropic porous media model was the same as the experimental value,and the model could well simulate the flow of blood in the oxygenator fiber bundle,but with the increase of flow,the deviation increases gradually;the internal velocity of the compound oxygenator was in a gradient form;the internal pressure was concentric and uniform,and the pressure value was positively correlated with the flow rate.The porous medium area was the main area of pressure loss,accounting for 87%of the overall pressure drop;the high incidence of blood damage was located at the blood inlet and outlet.Under the experimental flow,the standard hemolysis index NIH was 0.0492 g/100 L,which conformed to the general design requirements of oxygenator.The results were helpful for researchers to understand the influence of fluid motion characteristics on the performance of oxygenator,and could provide a reference for further performance improvement of oxygenator.

关 键 词：氧合器 多孔介质 微尺度 计算流体力学 溶血特性 

分 类 号：N945[自然科学总论—系统科学] TH789[机械工程—仪器科学与技术]