白细胞介素-6、白细胞介素-8和前B细胞克隆增强因子对儿童急性呼吸窘迫综合征的预后价值  

Prognostic value of interleukin-6,interleukin-8 and pre-B-cell colony-enhancing factor in children with acute respiratory distress syndrome

作　　者：李新叶 梁珍花[1] 代艳[1] 马红艳 唐慧荷 刘桂良[1] 黄翰武 LI Xinye;LIANG Zhenhua;DAI Yan;MA Hongyan;TANG Huihe;LIU Guiliang;HUANG Hanwu(Department of Pediatrics,People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西壮族自治区人民医院儿科,广西南宁530021

出　　处：《妇儿健康导刊》2022年第8期15-19,共5页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

基　　金：广西壮族自治区人民医院青年基金项目(QN2017-08)。

摘　　要：目的探讨白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和前B细胞克隆增强因子(PBEF)在儿童急性呼吸窘迫综合征(ARDS)预后中的价值。方法选取2017年11月至2019年1月在广西壮族自治区人民医院住院的35例ARDS患儿为研究对象,根据转归分为死亡组(15例)和幸存组(20例);同时选取同期15例健康儿童作为健康对照组。检测IL-6、IL-8和PBEF水平并比较在三组中的差异。结果ARDS患儿的血浆IL-6、IL-8、PBEF水平高于健康对照组(P<0.05)。死亡组小儿危重病例评分(PCIS)低于幸存组(P<0.001)。死亡组、幸存组的IL-6和IL-8水平高于健康儿童组(P<0.05),死亡组与幸存组的IL-6和IL-8水平比较,差异无统计学意义(P>0.05)。死亡组PBEF水平高于幸存组、健康儿童组(P=0.045、0.005),幸存组PBEF水平与健康儿童组比较,差异无统计学意义(P=0.436)。血浆PBEF水平与PCIS存在负相关(r=-0.452,P=0.018)。IL-6、IL-8与PCIS之间无相关性(P>0.05)。结论血浆IL-6、IL-8和PBEF与ARDS患儿的预后相关,PBEF对ARDS患儿预后评估有一定价值。Objective To explore the prognostic value of interleukin-6(IL-6),interleukin-8(IL-8)and pre-B-cell colony-enhancing factor(PBEF)in children with acute respiratory distress syndrome(ARDS).Methods A total of 35 children with ARDS who were hospitalized in People’s Hospital of Guangxi Zhuang Autonomous Region from November 2017 to January 2019 were selected as the research objects,and they were divided into non-surviving group(n=15)and surviving group(n=20)according to the outcome.Another 15 healthy children in the same period were selected as the healthy control group.The levels of IL-6,IL-8 and PBEF were detected and compared among these three groups.Results The levels of plasma IL-6,IL-8 and PBEF in children with ARDS were higher than those in the healthy control group(P<0.05).The pediatric critical index score(PCIS)of the non-surviving group was lower than that of the surviving group(P<0.001).The levels of IL-6 and IL-8 in the non-surviving group and the surviving group were higher than those in the healthy control group(P<0.05),and there were no statistical differences in IL-6 and IL-8 levels between the non-surviving group and the surviving group(P>0.05).The PBEF level of the non-surviving group was higher than that of the surviving group and the healthy control group(P=0.045,0.005).There was no statistical difference in the PBEF level between the surviving group and the healthy control group(P=0.436).There was a negative correlation between plasma PBEF level and PCIS(r=-0.452,P=0.018).There was no correlation between IL-6,IL-8 and PCIS(P>0.05).Conclusion IL-6,IL-8 and PBEF are related to the prognosis of children with ARDS,and PBEF has a certain value in the prognosis evaluation of children wit h ARDS.

关 键 词：急性呼吸窘迫综合征 白细胞介素-6 白细胞介素-8 前B细胞克隆增强因子 儿童 

分 类 号：R722.12[医药卫生—儿科]