维生素D对多囊卵巢综合征女性生育能力的影响  

Effect of vitamin D on fertility in women with polycystic ovary syndrome

作　　者：李燕 吴景丽[1] 曹丹[1] 李月 李婕娜 LI Yan;WU Jingli;CAO Dan;LI Yue;LI Jiena(Department of Gynaecology,Heze Municipal Hospital,Shandong Province,Heze,274000,China)

机构地区：[1]山东省菏泽市立医院妇科,山东菏泽274000

出　　处：《中国当代医药》2022年第22期46-49,共4页China Modern Medicine

摘　　要：目的探讨维生素D对多囊卵巢综合征(PCOS)女性生育力的影响。方法选择2019年12月至2021年5月于菏泽市立医院妇产科收治的25-羟基维生素D水平<20 ng/L的不孕女性270例为研究对象,按随机数字表法将其分为维生素D组与安慰剂组,各135例。维生素D组研究对象根据是否患有PCOS分为A组(n=75)与B组(n=60),安慰剂组研究对象根据是否患有PCOS分为C组(n=75)与D组(n=60)。比较各组间的25-羟基维生素D、卵泡刺激素(FSH)、黄体生成素(LH)、LH/FSH、抗苗勒管激素(AMH)、硫酸脱氢表雄酮(DHEAS)及雌二醇水平。比较A组和C组研究对象的月经恢复、排卵及妊娠情况。结果A组研究对象的25-羟基维生素D、FSH、DHEAS水平均高于C组,LH/FSH低于C组,差异有统计学意义(P<0.05)。A组与C组研究对象的LH、AMH、雌二醇水平比较,差异无统计学意义(P>0.05)。B组研究对象的25-羟基维生素D水平高于D组,差异有统计学意义(P<0.05)。B组与D组研究对象的FSH、LH、LH/FSH、AMH、雌二醇、DHEAS水平比较,差异无统计学意义(P>0.05)。A组研究对象的月经恢复率、排卵率均高于C组,差异有统计学意义(P<0.05)。A组与C组研究对象的妊娠率比较,差异无统计学意义(P>0.05)。结论维生素D可能改善PCOS女性内分泌激素水平状况,对女性生育能力有益。Objective To explore the effect of vitamin D on fertility indexes in women with polycystic ovary syndrome(PCOS).Methods A total of 270 infertile women with 25 hydroxyvitamin D level less than 20 ng/L admitted to department of gynecology and obstetrics in Heze Municipal Hospital from December 2019 to May 2021 were selected as the research objects.They were divided into vitamin D group and placebo group according to random number table method,with 135 cases in each group.The subjects in vitamin D group were divided into group A(n=75)and group B(n=60)according to whether they had PCOS.The subjects in the placebo group were divided into group C(n=75)and group D(n=60)according to whether they had PCOS.The levels of 25 hydroxyvitamin D,follicle-stimulating hormone(FSH),luteinizing hormone(LH),LH/FSH,anti-mullerian hormone(AMH),dehydroepiandrosterone sulfate(DHEAS)and estradiol were compared between the two groups.Menstrual recovery,ovulation and pregnancy were compared between group A and group C.Results The levels of 25 hydroxyvitamin D,FSH and DHEAS in group A were higher than those in group C,and the LH/FSH in group A was lower than that in group C,the differences were statistically significant(P<0.05).There were no significant differences in the levels of LH,AMH and estradiol between group A and group C(P>0.05).The level of 25 hydroxyvitamin D in group B was higher than that in group D,the difference was statistically significant(P<0.05).There were no significant differences in the levels of FSH,LH,LH/FSH,AMH,estradiol and DHEAS between group B and group D(P>0.05).The menstrual recovery rate and ovulation rate in group A were higher than those in group C,the differences were statistically significant(P<0.05).There was no significant difference in pregnancy rate between group A and group C(P>0.05).Conclusion Vitamin D may improve the level of endocrine hormone in women with PCOS,and have beneficial effect on fertility index.

关 键 词：维生素D 多囊卵巢综合征 抗苗勒管激素 生育指标 

分 类 号：R711.75[医药卫生—妇产科学]