Spirolindemers A and B,Lindenane Sesquiterpenoid Oligomers Equipped with Oxaspiro[4.5]decane from Chloranthus henryi  

作　　者：Jixin Li Jun Chi Pengfei Tang Yunpeng Sun Weijia Lu Wenjun Xu Yongyue Wang Jun Luo Lingyi Kong 

机构地区：[1]Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing,Jiangsu,210009 China

出　　处：《Chinese Journal of Chemistry》2022年第5期603-608,共6页中国化学（英文版）

基　　金：The authors acknowledge supports from the National Natural Science Foundation of China(No.32070389);the"Double First-Class"University project(CPU2018GY08).

摘　　要：Spirolindemers A and B,unprecedented lindenane sesquiterpenoid dimer(1)and trimer(2)equipped with oxaspiro[4.5]decane unit,were discovered from the medicinal plant Chloranthus henryi.Their structures including absolute configurations were achieved by HRMS,NMR,ECD,X-ray diffraction analyses,and quantum chemical calculations.Biogenetically,hetero-and homo-Diels-Alder additions may dominate the formation of oxaspiro[4.5]decane and spiro[4.5]decane skeletons,respectively.Compound 1 showed anti-inflammatory activity by inhibiting the expression of iNOS and COX-2.

关 键 词：Lindenane sesquiterpenoid oligomers Chloranthus henryi Natural products Structure elucidation Biological activity 

分 类 号：O62[理学—有机化学]